{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:54:19Z","timestamp":1772844859675,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:00:00Z","timestamp":1721347200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Observational studies have shown an association between skin microbiota and alopecia areata (AA), but the causal connection remains ambiguous.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We obtained data on skin microbiota and AA from summary statistics of Genome\u2010Wide Association Studies and applied statistical methods from Mendelian randomization (MR) to assess causal relationships. Additionally, we investigated whether the skin microbiota acts as a mediator in the pathway from gut microbiota to AA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the MR analysis of KORA FF4 and AA, the inverse\u2010variance weighting method indicated that\n                      <jats:italic>Corynebacterium<\/jats:italic>\n                      (odds ratio [OR]\u00a0=\u00a00.82, 95% confidence interval [CI]: 0.70\u20130.96,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02) and\n                      <jats:italic>asv037<\/jats:italic>\n                      (OR\u00a0=\u00a00.87, 95% CI: 0.76\u20130.99,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.05) exerted protective effects, while\n                      <jats:italic>Betaproteobacteria<\/jats:italic>\n                      (OR\u00a0=\u00a01.21, 95% CI: 1.01\u20131.44,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03),\n                      <jats:italic>asv015<\/jats:italic>\n                      (OR\u00a0=\u00a01.27, 95% CI: 1.05\u20131.54,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02), and\n                      <jats:italic>Burkholderiales<\/jats:italic>\n                      (OR\u00a0=\u00a01.20, 95% CI: 1.04\u20131.38,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.01) were identified as risk factors in AA. In the MR analysis of PopGen and AA,\n                      <jats:italic>asv001<\/jats:italic>\n                      (OR\u00a0=\u00a01.12, 95% CI: 1.01\u20131.24,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.04),\n                      <jats:italic>asv054<\/jats:italic>\n                      (OR\u00a0=\u00a01.13, 95% CI: 1.01\u20131.25,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03), and\n                      <jats:italic>asv059<\/jats:italic>\n                      (OR\u00a0=\u00a01.14, 95% CI: 1.02\u20131.27,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02) were found to potentially increase the risk in AA. Furthermore, in the influence of gut microbiota on AA, the skin microbiota did not act as a mediator.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our analysis suggests potential causal relationships between certain skin microbiota and AA, revealing insights into its pathogenesis and potential intervention strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.13845","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T23:05:47Z","timestamp":1721430347000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["RETRACTED: Gut microbiota, skin microbiota, and alopecia areata: A Mendelian randomization study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6751-2233","authenticated-orcid":false,"given":"Zishun","family":"Li","sequence":"first","affiliation":[{"name":"Second Clinical Medical College Henan University of Traditional Chinese Medicine  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changpu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Second Clinical Medical College Henan University of Traditional Chinese Medicine  Zhengzhou China"},{"name":"Department of Hepatobiliary and Gastroenterology Henan Provincial Hospital of Traditional Chinese medicine  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renwu","family":"Chen","sequence":"additional","affiliation":[{"name":"Second Clinical Medical College Henan University of Traditional Chinese Medicine  Zhengzhou 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