{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:51:29Z","timestamp":1788223889577,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T00:00:00Z","timestamp":1722643200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Lupus erythematosus (LE) is an inflammatory autoimmune disease, that can affect the skin to varying degree. In particular, discoid LE (DLE) and the rare form of lupus panniculitis\/profundus are associated with scarring alopecia. The heterogeneity of the clinical, dermatoscopic, and histologic presentation poses a major challenge to the clinician in the diagnosis and differential diagnosis of other forms of scarring alopecia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>While noninvasive imaging techniques using optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) have proven to be helpful in the diagnosis of scarring alopecia in the context of LE, this study aimed to investigate line\u2010field confocal OCT (LC\u2010OCT) to identify characteristic features of cicatricial alopecia in LE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifteen patients with cicatricial alopecia in LE were included and the most affected\/inflamed areas of the scalp were prospectively examined. In analogy to histopathology and previously reported criteria in RCM, all images were evaluated according to seven established criteria and underwent descriptive analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>LC\u2010OCT revealed characteristic features of cicatricial alopecia, such as lymphocytic interface dermatitis (14\/15; 93.3%) and basal cell vacuolization (13\/15; 86.7%). The most impressive feature was the occurrence of prominent hyperreflective fibers in 14\/15 patients (93.3%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LC\u2010OCT imaging can noninvasively detect morphologic criteria such as lymphocytic and vacuolar interface dermatitis of cicatricial alopecia due to LE. In particular, the presence of hyperreflective collagen fibers appears to be a characteristic easily recognizable feature that may facilitate differential diagnosis with other forms of cicatricial alopecia. Further studies are mandatory to differentiate other forms of scarring alopecia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.13859","type":"journal-article","created":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T07:13:46Z","timestamp":1722669226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Line\u2010field confocal optical coherence tomography: Characteristic hints for the diagnosis of scarring alopecia due to lupus erythematodes: A preliminary study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2981-8826","authenticated-orcid":false,"given":"Marie\u2010Christine","family":"Nutz","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy LMU University Hospital LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4935-9877","authenticated-orcid":false,"given":"Maximilian","family":"Deu\u00dfing","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy LMU University Hospital LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy LMU University Hospital LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabia","family":"Daxenberger","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy LMU University Hospital LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quirine Louise","family":"Eijkenboom","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy LMU University Hospital LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Gust","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy LMU University Hospital LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars E.","family":"French","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy LMU University Hospital LMU Munich  Munich Germany"},{"name":"Department of Dermatology and Cutaneous Surgery Miller School of Medicine University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Schuh","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital University of Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Welzel","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University Hospital University of Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke C.","family":"Sattler","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy LMU University Hospital LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-018-0363-8"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","unstructured":"HeilPM. Leitfaden durch die Vielfalt des kutanen Lupus erythematodes hautnah dermatologie.2022;38(1):32\u201039.","DOI":"10.1007\/s15012-021-6754-1"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-005-2638-9"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00393-013-1134-9"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.13498"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3315\/jdcr.2011.1083"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2014.06.016"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2009.03439.x"},{"issue":"4","key":"e_1_2_12_10_1","first-page":"129","article-title":"Cicatricial alopecia: do clinical, trichoscopic, and histopathological diagnosis agree?","volume":"30","author":"Abdel Bary A","year":"2021","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7753.130409"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12636"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07808.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10424.x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203320958141"},{"issue":"9","key":"e_1_2_12_16_1","first-page":"1111","article-title":"In vivo reflectance confocal microscopy features of discoid lupus erythematosus","volume":"11","author":"Wassef C","year":"2012","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00822.x"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203306074773"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12852"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14041082"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18324"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2023.06.050"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12949"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13495"},{"key":"e_1_2_12_25_1","first-page":"e267","article-title":"Line\u2010field confocal optical tomography\u2014a new diagnostic method in hair loss associated with folliculitis decalvans","volume":"38","author":"Kurzeja M","year":"2023","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.23736\/S2784-8671.23.07613-2"},{"issue":"12","key":"e_1_2_12_27_1","first-page":"2268","article-title":"Line\u2010field confocal optical coherence tomography (LC\u2010OCT) for skin imaging in dermatology","volume":"13","author":"Latriglia F","year":"2023","journal-title":"Life (Basel)"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000435914"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2010.01632.x"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.23.10.106007"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.13859","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T04:07:12Z","timestamp":1768104432000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.13859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/srt.13859"],"URL":"https:\/\/doi.org\/10.1111\/srt.13859","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"2024-07-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13859"}}