{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T15:57:39Z","timestamp":1789833459588,"version":"4.0.1"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:00:00Z","timestamp":1721347200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The effectiveness of negative\u2010pressure wound therapy (NPWT) in skin graft fixation has been demonstrated in several clinical studies. However, in vitro and in vivo studies on skin graft fixation with NPWT have been scarce. In this in vivo study, we aimed to determine whether NPWT fixation enhances skin graft survival and how it contributes to improving skin graft survival biologically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>We harvested skin from the bilateral abdominal wall of 88 mice after anesthetizing them. Full\u2010thickness skin grafts (FTSGs) were performed on contralateral harvest sites, and grafts were fixed using NPWT (continuous and intermittent modes), conventional compression methods, and wrapping with polyurethane foam as a control group. On days 5 and 10 of grafting, the survival rates of the FTSGs were evaluated. Immunohistopathological analysis and measurement of the expression levels of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (FGF\u20102), and epidermal growth factor (EGF) were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The survival rates of FTSG in the continuous NPWT group were significantly higher than those in the other groups. The number of capillaries in the dermis was significantly higher in the continuous NPWT group than in the other groups. In the wound bed, VEGF levels were significantly higher in both NPWT groups than in the other groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Continuous NPWT increases the survival rate of FTSGs and shortens the duration of skin graft survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.13865","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T22:55:11Z","timestamp":1721429711000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Continuous negative\u2010pressure wound therapy improves the survival rate of skin grafts and shortens the time required for skin graft survival"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6039-5169","authenticated-orcid":false,"given":"Masato","family":"Tsuchiya","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery National Defense Medical College  Tokorozawa Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1705-1467","authenticated-orcid":false,"given":"Toshihiro","family":"Kushibiki","sequence":"additional","affiliation":[{"name":"Department of Medical Engineering National Defense Medical College  Tokorozawa Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7019-7740","authenticated-orcid":false,"given":"Toshifumi","family":"Yamashiro","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery National Defense Medical College  Tokorozawa Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshine","family":"Mayumi","sequence":"additional","affiliation":[{"name":"Department of Medical Engineering National Defense Medical College  Tokorozawa Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6362-5014","authenticated-orcid":false,"given":"Miya","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Department of Medical Engineering National Defense Medical College  Tokorozawa Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7479-1779","authenticated-orcid":false,"given":"Ryuichi","family":"Azuma","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery National Defense Medical College  Tokorozawa Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,19]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Grabb and Smith's Plastic Surgery","author":"Chung KC","year":"2024"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2010.19.5.48046"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1984.tb01269.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.88B2.16923"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0b013e3182057376"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200111000-00045"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2004.11.016"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/08941930500328821"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0b013e31826af01a"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23952"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2010.00728.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2013.4544"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2016.08.025"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sap.0000245121.32831.47"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2012.01078.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000217745.56657.e5"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000133168.57199.E1"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.137.8.930"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000459038.81701.fb"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2014.12.025"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2012.09.019"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199706000-00001"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8090-5-75"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2021.11.003"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00504.2009"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.03.007"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107339"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2011.00747.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2016.25.3.154"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2018.02.064"},{"issue":"119","key":"e_1_2_10_32_1","article-title":"Murine full\u2010thickness skin transplantation","author":"Cheng CH","year":"2017","journal-title":"JoVE"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2017.26.Sup3.S1"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13415"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2021.05.010"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e31825aa9ea"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0b013e3181ea1e9b"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318171971a"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2006.00134.x"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2011.11.037"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9636"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2008.03.024"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13262"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1731792"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.9.11.3179"},{"key":"e_1_2_10_46_1","article-title":"The effects of variable, intermittent, and continuous negative pressure wound therapy, using foam or gauze, on wound contraction, granulation tissue formation, and ingrowth into the wound filler","volume":"12","author":"Malmsj\u00f6 M","year":"2012","journal-title":"Eplasty"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0b013e31816d78fe"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2005.04.008"},{"key":"e_1_2_10_49_1","first-page":"429","article-title":"The effects of epidermal growth factor and basic fibroblast growth factor on epithelialization of meshed skin graft interstices","volume":"365","author":"Cooper ML","year":"1991","journal-title":"Prog Clin Biol Res"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.56.4.3"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02644769"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1177\/09636897211041966"},{"issue":"1","key":"e_1_2_10_53_1","first-page":"1","article-title":"Immunomodulatory activity of human bone marrow and adipose\u2010derived mesenchymal stem cells prolongs allogenic skin graft survival in nonhuman primates","volume":"23","author":"Sotoodehnejadnematalahi F","year":"2021","journal-title":"Cell J"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2018.03.014"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000001051"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.13865","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/srt.13865","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.13865","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T20:57:41Z","timestamp":1769893061000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.13865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":54,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/srt.13865"],"URL":"https:\/\/doi.org\/10.1111\/srt.13865","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2024-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13865"}}