{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T09:49:45Z","timestamp":1769852985529,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Incontinence\u2010associated dermatitis (IAD) is a tough problem in clinical settings, not only increasing the risk of complications like catheter\u2010related urinary tract infections and pressure ulcers in elderly and critically ill patients, but also prolonging hospital stays, raising hospital costs, and possibly leading to medical disputes. This study is aimed to evaluate the therapeutic effect of silicone dressing combined with topical oxygen therapy on IAD in a rat model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An IAD rat model induced by synthetic urine with trypsin was established. Hematoxylin &amp; eosin staining was carried out to examine skin histology. Using immunofluorescence, the microvessel density in the affected skin tissues was determined. ELISA was performed to measure the concentrations of inflammatory cytokines and angiogenic factors in serum. The mRNA expression of EGF, PDGF, and VEGF was detected via qRT\u2010PCR. Western blotting was employed to determine NF\u2010\u03baB p65\/STAT1 pathway\u2010related protein levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to single therapy, silicone dressing combined with topical oxygen therapy could significantly reduce the severity of IAD, improve skin histology, inhibit inflammation, and promote angiogenesis in IAD rat models. Additionally, the results showed that relatively speaking, the combined therapy suppressed the NF\u2010\u03baB p65\/STAT1 signaling pathway more effectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings indicated that silicone dressing combined with topical oxygen therapy can alleviate IAD through promoting wound healing and inhibiting inflammation via NF\u2010\u03baB p65\/STAT1 signaling pathway in a rat model, which provided a theoretical basis for the prevention and treatment of IAD in clinic.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.13888","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T04:05:05Z","timestamp":1722830705000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Silicone dressing combined with topical oxygen therapy alleviates incontinence\u2010associated dermatitis via NF\u2010\u03baB p65\/STAT1 signaling pathway"],"prefix":"10.1111","volume":"30","author":[{"given":"Guiyu an","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Nursing School of Medicine, Jinhua Polytechnic  Jinhua Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingxun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Medicine Jinhua Municipal Central Hospital  Jinhua Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nursing School of Medicine, Jinhua Polytechnic  Jinhua Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shufeng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Jinhua People's Hospital  Jinhua Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louying","family":"Zhu","sequence":"additional","affiliation":[{"name":"Jinhua Center of Laboratory Animals Jinhua Municipal Food and Drug Inspection Institute  Jinhua Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2006-703X","authenticated-orcid":false,"given":"Mingxing","family":"Ding","sequence":"additional","affiliation":[{"name":"Medical Molecular Biology Laboratory School of Medicine, Jinhua Polytechnic  Jinhua Zhejiang 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