{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:50:56Z","timestamp":1783032656303,"version":"3.54.6"},"reference-count":7,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Trypanophobia or \u201cneedle phobia\u201d represents a potential hindrance to the effective management of chronic diseases whenever an injectable therapy might be required, especially in case of frequent administrations. Psoriasis, a chronic dermatologic disease, can be effectively treated with biologic drugs administered subcutaneously. Thankfully, anti\u2010IL\u201023 drugs require few administrations per year and are available in prefilled pens that hide the needle, thus representing a convenient option in patients with trypanophobia.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n An observational multicentric study was conducted on patients with moderate\u2010to\u2010severe psoriasis who were treated with 75\u00a0mg \u00d7 2 risankizumab prefilled syringe therapy for more than 6 months and reported a loss of efficacy measured by the Psoriasis Area and Severity Index (PASI)\u00a0from PASI 90 to PASI 75 attributed to a reduction of adherence due to trypanophobia. The patients were switched to 1 prefilled pen of risankizumab 150\u00a0mg and asked to fill out the Self\u2010Injection Assessment Questionnaire (SIAQ) before and after the injection at week 0 and at the following administration after 12\u00a0weeks. Subjects scored each item of the SIAQ on a 5\u2010point scale, scores were later transformed from 0 (worst experience) to 10 (best experience).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Twenty\u2010two patients were enrolled. The mean SIAQ predose domain scores were 5.5 for feelings about injection, 6.2 for self\u2010confidence, and 6.4 for satisfaction with self\u2010injection. After dose scores were higher\u00a0(>\u00a08.5) for each of the six domains at Week 0 and even higher after 12\u00a0weeks (>\u00a09.0).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n User\u2010friendly devices, such as prefilled pens, and a lower number of injections improved patient satisfaction in a group of patients with psoriasis on treatment with biologic drugs. We believe that treatment adherence could be positively influenced by such changes in the way of administration of a biologic treatment.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/srt.13902","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T06:44:35Z","timestamp":1724136275000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Improvement of self\u2010administration experience with a new injection device: Real\u2010life experience with risankizumab in patients with psoriasis"],"prefix":"10.1111","volume":"30","author":[{"given":"Alexandra Maria Giovanna","family":"Brunasso","sequence":"first","affiliation":[{"name":"Unit of Dermatology Villa Scassi Hospital ASL3 Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Salvi","sequence":"additional","affiliation":[{"name":"Section of Dermatology Department of Health Sciences (DiSSal) University of Genoa Genoa Italy"},{"name":"IRCCS San Martino University Hospital Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Sorbara","sequence":"additional","affiliation":[{"name":"Division of Dermatology EO Galliera Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Muracchioli","sequence":"additional","affiliation":[{"name":"Unit of Dermatology San Bartolomeo Hospital La Spezia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"De Col","sequence":"additional","affiliation":[{"name":"Unit of Dermatology Civil Hospital of Imperia Imperia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Baldari","sequence":"additional","affiliation":[{"name":"Unit of Dermatology Civil Hospital of Sestri Levante Sestri Levante Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Parodi","sequence":"additional","affiliation":[{"name":"Section of Dermatology Department of Health Sciences (DiSSal) University of Genoa Genoa Italy"},{"name":"IRCCS San Martino University Hospital Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Cozzani","sequence":"additional","affiliation":[{"name":"Section of Dermatology Department of Health Sciences (DiSSal) University of Genoa Genoa Italy"},{"name":"IRCCS San Martino University Hospital Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4381-6718","authenticated-orcid":false,"given":"Martina","family":"Burlando","sequence":"additional","affiliation":[{"name":"Section of Dermatology Department of Health Sciences (DiSSal) University of Genoa Genoa Italy"},{"name":"IRCCS San Martino University Hospital Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jan.13818"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0276814"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S375037"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574886315666200128095958"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2021.01.009"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-9-2"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2023.2174970"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.13902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T04:06:42Z","timestamp":1768104402000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.13902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":7,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/srt.13902"],"URL":"https:\/\/doi.org\/10.1111\/srt.13902","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"2024-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13902"}}