{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:14:31Z","timestamp":1772756071039,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the causal relationship between inflammatory skin diseases (atopic dermatitis, and psoriasis) and IgA nephropathy using Mendelian randomization and enrichment analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The instrumental variables (IVs) in the European Bioinformatics Institute (EBI) database were used for two\u2010sample MR analysis. The results of inverse variance weighting (IVW) were used as the main method, the MR\u2212Egger method was used for pleiotropy analysis and the leave\u2010one\u2010out method was used for sensitivity analysis to verify the reliability of the data. Combined with the human genome database GeneCards database and Metascape enrichment analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      People with AD had an increased risk of IgA nephropathy (IVW: OR\u00a0=\u00a01.06, 95% CI [1.0002\u20131.1248],\n                      <jats:italic>p<\/jats:italic>\n                      =\u00a00.0491). Psoriasis and IgA nephropathy (IVW: OR\u00a0=\u00a00.97, 95% CI [0.9394\u20131.0055],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.1002) no statistical significance, therefore cannot prove cause\u2010and\u2010effect relationship between.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides evidence that atopic dermatitis is associated with an increased risk of IgA nephropathy, but does not provide evidence that psoriasis is causologically associated with IgA nephropathy. Enrichment analysis suggested a causal relationship between inflammatory skin diseases and IgA nephropathy at the genetic level.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.13915","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T12:50:56Z","timestamp":1723207856000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["RETRACTED: Causal relationship between inflammatory skin diseases and immunoglobulin A nephropathy: A Mendelian randomization and enrichment analysis study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9914-5974","authenticated-orcid":false,"given":"Chundi","family":"Li","sequence":"first","affiliation":[{"name":"The First School of Clinical Medicine Liaoning University of Traditional Chinese Medicine  Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baisen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Hospital of Liaoning University of Traditional Chinese Medicine  Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianrun","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Hospital of Liaoning University of Traditional Chinese Medicine  Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine Liaoning University of Traditional Chinese Medicine  Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Hospital of Liaoning University of Traditional Chinese Medicine  Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2021.01.024"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2020.10.003"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/2175\u20108239\u2010JBN\u20102020\u20100101"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002586"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20067"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1346"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010021\u201000931\u2010x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xhgg.2021.100069"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016010098"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010021\u201000757\u20101"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.928944"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1037"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwt084"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.10.025"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.639103"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/immunohorizons.2300042"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13782"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13841"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13715"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157\u2010019\u201001700\u20101"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13730\u2010019\u201000393\u20105"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000015433"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.10090"},{"issue":"1","key":"e_1_2_8_25_1","first-page":"97","article-title":"Current developments in the immunology of psoriasis","volume":"93","author":"Gr\u00e4n F","year":"2020","journal-title":"Yale J Biol Med"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467\u2010014\u20102835\u20102"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.20394"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390\u2010022\u201002080\u20101"}],"updated-by":[{"DOI":"10.1111\/srt.70265","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000}},{"DOI":"10.1111\/srt.70265","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"record-id":"69548"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.13915","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T04:06:14Z","timestamp":1768104374000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.13915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/srt.13915"],"URL":"https:\/\/doi.org\/10.1111\/srt.13915","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"2024-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13915"}}