{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T23:16:08Z","timestamp":1775862968866,"version":"3.50.1"},"reference-count":58,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neutrophil extracellular traps (NETs) are related to the prognosis of cancer patients. Nevertheless, the potential prognostic values of NETs in skin cutaneous melanoma (SKCM) remains largely unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>The NET\u2010related gene signature was constructed by LASSO Cox regression analysis using the TCGA\u2010SKCM cohort. The overall survival (OS) and immune status in SKCM patients between the high\u2010 and low\u2010NET score (high\u2010score, low\u2010score) groups were explored. The scRNA\u2010seq dataset GSE115978 was used to understand the role of NET score in SKCM at single cell resolution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A five NET genes\u2010based signature (TLR2, CLEC6A, PDE4B, SLC22A4 and CYP4F3) was constructed as the NET\u2010related prognostic model for SKCM. The OS of SKCM patients with low\u2010score was better than that in patients with high\u2010score. Additionally, NET score was negatively associated with infiltration of some immune cells (e.g. type I Macrophages, CD8\u2010T cells, CD4\u2010T cells). Moreover, patients with high\u2010score had low stromal, immune and ESTIMATE scores. Furthermore, drug sensitivity analysis results showed that Lapatinib, Trametinib and Erlotinib may have better therapeutic advantages in patients with high\u2010score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We established a NET\u2010related five gene signature in SKCM and found that the NET\u2010related signature may exhibit a good predictive ability for SKCM prognosis. The NET score may not only predict the survival outcome and drug sensitivity in SKCM, but also reflect the immune conditions of SKCM patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.70008","type":"journal-article","created":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T22:58:39Z","timestamp":1724281119000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neutrophil extracellular trap related risk score exhibits crucial prognostic value in skin cutaneous melanoma, associating with distinct immune characteristics"],"prefix":"10.1111","volume":"30","author":[{"given":"Haiyang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hand and Foot Surgery Zibo Central Hospital  Zibo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqing","family":"Bi","sequence":"additional","affiliation":[{"name":"Dermatology&amp;S.T.D. 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