{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T01:27:54Z","timestamp":1784165274463,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Laser technology is a viable therapeutic option for treating a number of skin pathologic conditions, including pigmented lesions, vascular lesions and acne scars.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>In this work, through in vitro and clinical investigations\u00a0we test the efficacy, the safety and the speed of treatment of high\u2010powered laser system emitting a 675\u2010nm in the management of various skin condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      In vitro experiments were performed irradiating adult human dermal fibroblasts cells (HDFa) with 675\u2010nm laser for 24, 48 and 72\u00a0h with different fluences and Ki\u201067\n                      <jats:sup>+<\/jats:sup>\n                      cells were counted. The confocal microscopy images of control and treated samples were acquired. Clinical skin rejuvenation\/diseases treatments with 675\u00a0nm laser device were performed with different laser parameters in 11 patients with pigmented lesions, 5 patients with acne scars and 23 patients for skin rejuvenation. Data were evaluated with the validated global score using 5\u2010point scales (GAIS) and patient's satisfaction scale.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The application of the high\u2010power 675\u00a0nm laser has proven effective in stimulating cell proliferation in in vitro experiments and it led to good results for all skin pathologies. GAIS showed values between 3 and 4 points for all treated pathologies, all scores between \u201875%\u2010good improvements\u2019 and \u2018100%\u2010excellent improvements\u2019. The treatment time was reduced by 50% compared to the old parameters setting, resulting in a faster and good patient's satisfying technique. No serious adverse effects were recorded. Conclusion: the preclinical and clinical data confirm the efficacy and safety of this high\u2010powered 675\u00a0nm laser for several skin condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.70019","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T06:50:17Z","timestamp":1724914217000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["RETRACTED: High\u2010powered 675\u2010nm laser: Safety and efficacy in clinical evaluation and in vitro evidence for different skin disorders"],"prefix":"10.1111","volume":"30","author":[{"given":"Massimo D. F.","family":"Vitale","sequence":"first","affiliation":[{"name":"Polyclinic of San Domenico Private Practice  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Madeddu","sequence":"additional","affiliation":[{"name":"El.En. Group  Calenzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7264-8808","authenticated-orcid":false,"given":"Irene","family":"Fusco","sequence":"additional","affiliation":[{"name":"El.En. Group  Calenzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pieri","sequence":"additional","affiliation":[{"name":"El.En. Group  Calenzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Bonan","sequence":"additional","affiliation":[{"name":"Laser Cutaneous Cosmetic and Plastic Surgery Unit Villa Donatello Clinic  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziano","family":"Zingoni","sequence":"additional","affiliation":[{"name":"El.En. 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