{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T09:22:34Z","timestamp":1775121754571,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100014804","name":"Neurofibromatosis Therapeutic Acceleration Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cutaneous neurofibromas (cNFs) are a major cause of disfigurement in patients with Neurofibromatosis Type 1 (NF1). However, clinical trials investigating cNF treatments lack standardised outcome measures to objectively evaluate changes in cNF size and appearance. 3D imaging has been proposed as an objective standardised outcome measure however various systems exist with different features that affect useability in clinical settings. The aim of this study was to compare the accuracy, precision, feasibility, reliability and accessibility of three imaging systems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>We compared the Vectra\u2010H1, LifeViz\u2010Micro and Cherry\u2010Imaging systems. A total of 58 cNFs from 13 participants with NF1 were selected for imaging and analysis. The primary endpoint was accuracy as measured by comparison of measurements between imaging systems. Secondary endpoints included reliability between two operators, precision as measured with the average coefficient of variation, feasibility as determined by time to capture and analyse an image and accessibility as determined by cost.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was no significant difference in accuracy between the three devices for length or surface area measurements (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&gt;\u00a00.05), and reliability and precision were similar. Volume measurements demonstrated the most variability compared to other measurements; LifeViz\u2010Micro demonstrated the least measurement variability for surface area and image capture and analysis were fastest with LifeViz\u2010Micro. LifeViz\u2010Micro was better for imaging smaller number of cNFs (1\u20133), Vectra\u2010H1 better for larger areas and Cherry for uneven surfaces.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>All systems demonstrated excellent reliability but possess distinct advantages and limitations. Surface area is the most consistent and reliable parameter for measuring cNF size in clinical trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.70020","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T07:32:05Z","timestamp":1725348725000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparing 3D imaging devices for the measurement of cutaneous neurofibromas in patients with Neurofibromatosis Type 1"],"prefix":"10.1111","volume":"30","author":[{"given":"Jonathan C. L.","family":"Lau","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health, Sydney Medical School The University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Clinical Genetics Royal North Shore Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Fleming","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, Sydney Medical School The University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Clinical Genetics Royal North Shore Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Good","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Royal North Shore Hospital  Sydney New South Wales 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Dermatology Royal North Shore Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Schlub","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sydney School of Public Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue\u2010Faye","family":"Siow","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, Sydney Medical School The University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Clinical Genetics Royal North Shore Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanette","family":"Lacson","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Royal North Shore Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Romo","sequence":"additional","affiliation":[{"name":"Department of Neurology John Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaishri","family":"Blakely","sequence":"additional","affiliation":[{"name":"Department of Neurology John Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Bergqvist","sequence":"additional","affiliation":[{"name":"Department of Dermatology, National Referral Center for Neurofibromatoses, Henri\u2010Modor Hospital Assistance Publique\u2010Hopital Paris (AP\u2010HP)  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2495-4928","authenticated-orcid":false,"given":"Yemima D.","family":"Berman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, Sydney Medical School The University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Clinical Genetics Royal North Shore Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.465"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-021-01170-5"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/111.6.1355"},{"key":"e_1_2_11_5_1","first-page":"i107","article-title":"Management of cutaneous neurofibroma: current therapy and future directions","volume":"2","author":"Chamseddin BH","year":"2020","journal-title":"Neurooncol 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