{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T17:55:25Z","timestamp":1770832525764,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Radiodermatitis (RD) is an inflammatory lesion of skin mucosa caused by radiation, which causes itching and pain in patients' skin.\n                      <jats:italic>Hypericum sampsonii<\/jats:italic>\n                      has an anti\u2010inflammatory effect. This study aims to explore the potential effect and mechanism of\n                      <jats:italic>H. sampsonii<\/jats:italic>\n                      on RD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      The RD model was established using X\u2010ray irradiation of mice and the pain response of mice under different treatment methods. Serum levels of IL\u20101\u03b2, IL\u20106, and TNF\u2010\u03b1 were measured by ELSA. The RD cell model was constructed by RAW264.7 cell,\n                      <jats:italic>H. sampsonii<\/jats:italic>\n                      intervention was conducted, and the changes of the NLRP3 inflammasome in the cells were detected by qRT\u2010PCR. The cells were stimulated with LPS and the protein changes of TLR4\/NF\u2010\u03baB were investigated by Western Blotting.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>H. sampsonii<\/jats:italic>\n                      can better improve the skin status of RD mice, relieve pain, and reduce the secretion of serum inflammatory factors IL\u20101\u03b2, IL\u20106, and TNF\u2010\u03b1.\n                      <jats:italic>H. sampsonii<\/jats:italic>\n                      significantly down\u2010regulated the expression of NLRP3, Caspase\u20101, pro IL\u20101\u03b2, and IL\u20101\u03b2. Lps\u2010induced activation of the TLR4\/NF\u2010\u03baB pathway promotes the expression of NLRP3 and pro\u2010IL\u20101\u03b2, and\n                      <jats:italic>H. sampsonii<\/jats:italic>\n                      can inhibit this promotion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>H. sampsonii<\/jats:italic>\n                      may inhibit NLRP3 inflammatory vesicle activation via interfering with TLR4\/NF\u2010\u03baB signaling to reduce the inflammatory response in macrophages and thus play a role in the treatment of RD.\n                    <\/jats:p>\n                  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