{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:48:16Z","timestamp":1784958496347,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2019YFC1709900"],"award-info":[{"award-number":["2019YFC1709900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acanthosis nigricans (AN) is a common skin disease characterized by clear pigmented patches on the folds of the skin. However, the AN research field lacks scientific and comprehensive bibliometric analysis. This article aims to use bibliometric methods to summarize and visualize the distribution patterns, research hotspots, and development trends of AN literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Literature from 1900 to 2024 was retrieved from the Web of Science Core Collection database through AN's thematic search. Using CiteSpace, VOSviewer, and Excel 2019, conduct a comprehensive analysis of the number of publications, countries\/regions, institutions, authors, journals, highly cited literature, keywords, and so on, and sort out the hotspots and directions of AN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From 1900 to 2024, 1675 publications were included in the bibliometric analysis, showing a steady annual increase in the number of publications. The United States leads in this research field, with the University of Texas System being a key research institution. The\n                      <jats:italic>Journal of Clinical Endocrinology &amp; Metabolism<\/jats:italic>\n                      has the highest number of published papers. The most cited article is \u201cSyndromes of Insulin Resistance and Acanthosis Nigricans: Insulin\u2010Receptor Disorders in Man\u201d (1976). The author Taylor, SI, has published the most papers. \u201cAcanthosis nigricans\u201d is the most frequently occurring keyword. The main research hotspots and frontier areas in AN research are as follows: (1) The relationship between AN and other diseases is a popular research topic; (2) The connection between AN and insulin resistance (IR) is a current research focus; (3) Treatment of AN, with an emphasis on addressing the underlying causes and improving local skin conditions, represents the cutting edge of this field.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study summarizes the research trends and hotspots in the field of AN, offering valuable information and insights for scholars focused on AN scientific research, and providing a reference for future research directions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.70054","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T09:25:12Z","timestamp":1726046712000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Global hotspots and trends in Acanthosis nigricans research: A bibliometric and visualized analysis"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5445-484X","authenticated-orcid":false,"given":"Shaobo","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Acupuncture and Tuina Changchun University of Chinese Medicine  Changchun Jilin P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3911-6903","authenticated-orcid":false,"given":"Huixin","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Tuina Changchun University of Chinese Medicine  Changchun Jilin P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weichen","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Tuina Changchun University of Chinese Medicine  Changchun Jilin P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingnan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Tuina Changchun University of Chinese Medicine  Changchun Jilin P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Tuina Changchun University of Chinese Medicine  Changchun Jilin P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Hubei University of Chinese Medicine  Wuhan Hubei P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bailin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Acupuncture and Tuina Changchun University of Chinese Medicine  Changchun Jilin P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingquan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Tuina Affiliated Hospital of Changchun University of Traditional Chinese Medicine  Changchun Jilin P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijd.IJD_160_19"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13544"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.33706"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_249_17"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2906189"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.3896"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijd.ijd_442_21"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13428"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756\u20100500\u20104\u201025"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573396318666220429085231"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S137527"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1025861"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13538"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13036\u2010024\u201000435\u20102"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000035305"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.18007"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1322319"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13815"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13694"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.59556\/japi.72.0569"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048\u2010023\u201001335\u20107"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2024.2352136"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.37809"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102019\u2010231749"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2017.09.013"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.1104a131"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mjafi.2024.04.011"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12102519"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.4081\/dr.2021.8799"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.970733"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvad169"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24479"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.1165"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.11.014"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00788"},{"issue":"12","key":"e_1_2_12_37_1","first-page":"917","article-title":"[Obese children with benign acanthosis nigricans and insulin resistance: analysis of 19 cases]","volume":"42","author":"Fu J fen","year":"2004","journal-title":"Zhonghua Er Ke Za Zhi Chin J Pediatr"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eprac.2023.10.134"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.5223\/pghn.2016.19.4.251"},{"key":"e_1_2_12_40_1","unstructured":"Acanthosis nigricans as a clinical marker of insulin resistance among overweight adolescents\u2014PubMed. Accessed August 1 2024.https:\/\/pubmed.ncbi.nlm.nih.gov\/31261473\/"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.7727\/wimj.2013.334"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346\u20108138.12052"},{"key":"e_1_2_12_43_1","unstructured":"A study of pathogenesis of acanthosis nigricans and its clinical implications\u2014PubMed. Accessed August 1 2024.https:\/\/pubmed.ncbi.nlm.nih.gov\/22345770\/"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13206"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229\u20105178.137765"},{"issue":"9","key":"e_1_2_12_46_1","first-page":"1151","article-title":"Palliative treatment of paraneoplastic acanthosis nigricans and oral florid papillomatosis with retinoids","volume":"9","author":"Swineford SL","year":"2010","journal-title":"J Drugs Dermatol JDD"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1708855"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1K446"},{"key":"e_1_2_12_49_1","unstructured":"Melatonin Treatment Improves Insulin Resistance and Pigmentation in Obese Patients with Acanthosis Nigricans\u2014PubMed. Accessed August 1 2024.https:\/\/pubmed.ncbi.nlm.nih.gov\/29706998\/"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.70054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/srt.70054","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.70054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T20:57:19Z","timestamp":1769893039000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.70054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":48,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/srt.70054"],"URL":"https:\/\/doi.org\/10.1111\/srt.70054","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"2024-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70054"}}