{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T19:46:11Z","timestamp":1775677571189,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Cold plasma has shown efficacy in various dermatological applications by reduces inflammatory responses and modulating cytokine expression. Therefore, this study aimed to investigate the therapeutic effects of cold plasma on psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In psoriasis HaCaT cells with cold plasma, we confirmed the expression of inflammatory cytokines involved in psoriasis formation and MAPK pathway, cell cycle, and apoptosis\u2010related factors. In psoriasis\u2010like BALB\/c mice model, the effects of cold plasma treatment on skin were visually assessed. The expression of psoriasis\u2010related factors was confirmed through qPCR, Western blotting, and Immunohistochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cold plasma led to a reduction in inflammatory cytokines including IL\u201017A, IL\u201023A, IL\u201024, IL\u20101\u03b2, and TNF\u2010\u03b1 in the psoriasis cell line. It also modulated factors involved in the MAPK pathway and the cell cycle. In the psoriasis\u2010like mice model, cold plasma resulted in improvements in skin thickness, erythema, scaling, and PASI. Additionally, decreases in inflammatory cytokines like INF\u2010\u03b3, IL\u201023, and S100a7 were observed, along with improvements in MAPK pathway activation, apoptosis, and other psoriasis\u2010related factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Through in vitro and in vivo studies, our research highlights the potential of cold plasma as a novel therapeutic approach for psoriasis. Furthermore, cold plasma could serve as an adjunctive treatment for skin immunological diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.70071","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T21:44:26Z","timestamp":1727732666000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cold Plasma Ameliorates Imiquimod\u2010Induced Psoriasis\u2010Like Skin Inflammation in Mice"],"prefix":"10.1111","volume":"30","author":[{"given":"Yu\u2010Jin","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology, College of Medicine Chung\u2010Ang University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2320-7621","authenticated-orcid":false,"given":"Beom Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Chung\u2010Ang University Hospital 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