{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:18:28Z","timestamp":1767165508261,"version":"build-2238731810"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To investigate the screening value of a small\u2010molecule probe to assess the methylation of PAX1 in cervical cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      The diagnostic threshold of the grayscale values for cervical lesions was assessed by plotting the Receiver Operating Characteristic (ROC) curve of subjects. Grayscale values were significantly different among the four groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Compared with the LSIL and cervicitis groups, a considerably higher grayscale value was found in the CA and high\u2010grade squamous intraepithelial lesion (HSIL) groups (both\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The differential ROC curves of the grayscale values showed that the diagnostic Area Under Curve of the probe for cervicitis and low\u2010grade squamous intraepithelial lesion (LSIL) was 0.8724 (95% CI\u00a0=\u00a00.7762\u20130.9685,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001), for cervicitis and CA was 1.0000 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001), for the LSIL and HSIL was 0.5484 (95% CI = 0.3826\u20130.7142,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.5755), and for the LSIL and CA was 0.7724 (95% CI = 0.6016\u20130.9432,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0138).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The small molecular probe has certain application value in differentiating the type of cervical lesions and has better efficacy in distinguishing cervical inflammatory and precancerous lesions from carcinogenesis, but less efficacy in determining the type of precancerous lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.70074","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T16:15:05Z","timestamp":1727453705000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["RETRACTED: Preliminary Evaluation of the Value of a Small\u2010Molecule Probe Targeting DNMT1 in Detecting the Methylation of PAX1 in Cervical Cancer"],"prefix":"10.1111","volume":"30","author":[{"given":"Baohua","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Minhang Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qunxian","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Minhang Hospital Fudan University  Shanghai 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