{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:07:39Z","timestamp":1791544059997,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background and objectives<\/jats:title>\n Facial photoaging is a type of facial skin aging induced mainly by exogenous factors (ultraviolet radiation) and often manifests itself in the form of hyperpigmentation, telangiectasia, roughness, increase in fine lines\/wrinkles, and enlarged pores. Recently, picosecond lasers have become an emerging option for the treatment of facial photoaging, and long\u2010pulse alexandrite lasers (LPAL) have demonstrated promising potential in the treatment of photoaging\u2010related symptoms. This study aimed to evaluate the efficacy and safety of picosecond alexandrite laser (PSAL) with diffractive lens array (DLA) combined with LPAL for facial photoaging.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This is a retrospective study of 20 Chinese female patients with facial photoaging who received PSAL with DLA combined with LPAL during a 1\u2010year period. All patients were treated every 4\u00a0weeks for a total of three treatments. Objective indicators of facial photoaging and patient satisfaction were evaluated before each treatment, and pain scores and adverse effects were recorded after each treatment.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Compared with baseline, patients showed significant differences in all facial photoaging indices (\n p<\/jats:italic>\n \u00a0<\u00a00.01). After receiving three treatments, there was a 20.1% decrease in the pigmentation index, a 23.9% decrease in the erythema index, a 34.5% decrease in the texture index, a 28.4% decrease in the fine lines index, a 56% decrease in the pore index, a 9.3% elevation and a 17.1% decrease in elasticity R2 and F4, respectively, and a 55% decrease in sebum content. The mean satisfaction score for the three treatments was 4.67 (3.33, 5.00), and the mean visual analogue scale (VAS) pain score was 7.00. No serious adverse effects such as post\u2010inflammatory hyperpigmentation (PIH), hypopigmentation, or blistering were observed at the treatment site during the treatment period.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n PSAL with DLA combined with LPAL for the treatment of facial photoaging with significant efficacy, high patient satisfaction, and minimal adverse effects.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/srt.70091","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T22:59:01Z","timestamp":1727996341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Picosecond Alexandrite Laser With Diffractive Lens Array Combined With Long\u2010Pulse Alexandrite Laser for the Treatment of Facial Photoaging in Chinese Women: A Retrospective Study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2780-8777","authenticated-orcid":false,"given":"Changhan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Cosmetology Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated Zhejiang Chinese Medical University Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youhui","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Cosmetology Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated Zhejiang Chinese Medical University Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03963.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08108.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-016-0185-5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12715"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.13924"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2017.12.002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22540"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-021-03329-7"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23244"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14810"},{"issue":"11","key":"e_1_2_9_12_1","first-page":"1390","article-title":"A Prospective Split\u2010Face Study of the Picosecond Alexandrite Laser With Specialized Lens Array for Facial Photoaging in Chinese","volume":"15","author":"Ge Y.","year":"2016","journal-title":"Journal of Drugs in Dermatology"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S441169"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12145"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-022-03704-y"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000657"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2013.3665"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23581"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23014"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000010379"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2011.05.006"},{"issue":"3","key":"e_1_2_9_22_1","first-page":"134","article-title":"Skin Tightening","volume":"106","author":"Kwan K. R.","year":"2020","journal-title":"Cutis; Cutaneous Medicine for the Practitioner"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-016-1899-6"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13484"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13391"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.70091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T21:23:34Z","timestamp":1759958614000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.70091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/srt.70091"],"URL":"https:\/\/doi.org\/10.1111\/srt.70091","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70091"}}