{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:09:52Z","timestamp":1785402592541,"version":"3.56.0"},"reference-count":60,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Koenigia alpina<\/jats:italic> (All.) T.M.Schust. &amp; Reveal (alpine knotweed) is a perennial herb belonging to the Polygonaceae family. Several studies have examined Polygonaceae species\u2019 potential applications as cosmeceutical materials; however, the potential of <jats:italic>K. alpina<\/jats:italic> as a cosmeceutical has not yet been studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>) and lipopolysaccharide were used to induce an inflammatory response in RAW 264.7 cells. 2,2\u2010Diphenyl\u20101\u2010picrylhydrazyl (DPPH) radicals and H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> were used to evaluate the free\u2010radical scavenging activity of <jats:italic>K. alpina<\/jats:italic> extract and its protective effect against reactive oxygen species (ROS)\u2010induced cell damage. The whitening, antiaging, and cell proliferation\/migration effects of the extracts were evaluated via tyrosinase inhibition, collagenase\/elastase inhibition, and wound healing assays, respectively. The anti\u2010inflammatory effect was confirmed by evaluating nitric oxide (NO) production in RAW 264.7 cells. High\u2010performance liquid chromatography (HPLC), UV, and MS\/MS were used to determine the main components of the extract and fractions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ethyl acetate (EA) fraction and its aglycone fraction showed very high free\u2010radical scavenging activities (47.5 and 47.1\u00a0\u00b5g\/mL, respectively). The extract\/fractions also showed significant tyrosinase inhibition (IC<jats:sub>50<\/jats:sub> = 0.38\u00a0mg\/mL in EA fraction), collagenase inhibition (IC<jats:sub>50<\/jats:sub> = 0.21\u00a0mg\/mL in EA fraction), and elastase inhibition (IC<jats:sub>50<\/jats:sub> = 0.57\u00a0mg\/mL in aglycone fraction). NO production in lipopolysaccharide\u2010induced RAW 264.7 cells was inhibited by the extract\/fractions. The extract also promoted the closure of scratch wounds in HaCaT cells. The <jats:italic>K. alpina<\/jats:italic> extract\/fractions contained cardamonin, quercetin, and quercitrin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>K. alpina<\/jats:italic> extracts\/fractions showed antioxidant, antiaging, whitening, and anti\u2010inflammatory activities, suggesting they may have potential as antiaging cosmeceuticals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.70102","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T11:08:51Z","timestamp":1728558531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Functional Properties and Components of <i>Koenigia alpina<\/i> Extract"],"prefix":"10.1111","volume":"30","author":[{"given":"Kwan\u2010Woo","family":"Lee","sequence":"first","affiliation":[{"name":"ISTY ON NATURE  Suwon\u2010si Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su\u2010Hyun","family":"Mun","sequence":"additional","affiliation":[{"name":"NBBIO Company  Suwon\u2010si Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon\u2010A","family":"Kim","sequence":"additional","affiliation":[{"name":"NBBIO Company  Suwon\u2010si Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo\u2010Rim","family":"Kim","sequence":"additional","affiliation":[{"name":"NBBIO Company  Suwon\u2010si Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0901-5711","authenticated-orcid":false,"given":"Qinglong","family":"Jin","sequence":"additional","affiliation":[{"name":"NBBIO Company  Suwon\u2010si Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Ki","family":"Lee","sequence":"additional","affiliation":[{"name":"NBBIO Company  Suwon\u2010si Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Nam","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biohealth Engineering College of Science and Convergence Technology Seoul Women's University  Nowon\u2010gu Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"75","article-title":"Skin Aging and Antioxidants","volume":"23","author":"Park S. 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