{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:07:52Z","timestamp":1788998872783,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Melasma is a chronic pigmented lesion on the face that is challenging to treat. Single laser treatments are usually ineffective. Recently, picosecond lasers are becoming an emerging option for the treatment of melasma. This study aimed to evaluate the efficacy and safety of fractional and non\u2010fractional picosecond Nd:YAG lasers (PSNL) combined with fractional picosecond KTP laser (PSKL) on melasma in female Chinese.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010eight Chinese patients with facial melasma were selected and divided into two groups. Every 4 weeks, each patient received one treatment, for a total of six treatments. Treatment was administered to 24 patients using fractional and non\u2010fractional PSNL in the Nd:YAG group and fractional PSKL combined with fractional and non\u2010fractional PSNL in the Nd:YAG+KTP group. Pain scores and adverse reactions were noted following each treatment, and the modified Melasma Area Severity Index (mMASI) and patient satisfaction were assessed 1 month following every two treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mMASI scores of both groups showed a considerable decline from the baseline. Following six treatments, the Nd:YAG+KTP group's mean mMASI score was 2.29 \u00b1 0.82, while the Nd:YAG group was 2.87 \u00b1 0.68. This difference was statistically significant (<jats:italic>p<\/jats:italic> &lt; 0.05). At every stage of the procedure, the Nd:YAG+KTP group experienced higher patient satisfaction than the Nd:YAG group. In comparison to the Nd:YAG group, which had a pain score of 2.75 (2.54, 3.00), the Nd:YAG+KTP group had a higher pain score of 3.00 (3.00, 3.17). During the study, no severe side effects were seen in the treated areas, including blisters, hypopigmentation, or post\u2010inflammatory hyperpigmentation (PIH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The efficacy of fractional and non\u2010fractional PSNL combined with fractional PSKL in the treatment of melasma is significantly better than that of using single wavelength fractional and non\u2010fractional PSNL, with higher patient satisfaction and less adverse reactions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.70177","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T10:12:19Z","timestamp":1754043139000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fractional and Non\u2010Fractional Picosecond Nd:YAG Lasers Combined With Fractional Picosecond KTP Laser for the Treatment of Melasma in Female Chinese"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2780-8777","authenticated-orcid":false,"given":"Changhan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Cosmetology Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Affiliated Zhejiang Chinese Medical University  Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youhui","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Cosmetology Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Affiliated Zhejiang Chinese Medical University  Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13844"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1962.136"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1967.03120090043007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04337.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-019-00488-w"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-022-03514-2"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23244"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2022.2033674"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000009994"},{"issue":"11","key":"e_1_2_9_11_1","first-page":"1077","article-title":"Treatment of Photoaging With a Dual\u2010Wavelength, 532 Nm and 1,064 Nm Picosecond\u2010Domain Laser Producing a Fractionated Treatment Beam Using a Holographic Optic","volume":"16","author":"Bernstein E. F.","year":"2017","journal-title":"Journal of Drugs in Dermatology"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14654"},{"issue":"11","key":"e_1_2_9_13_1","first-page":"1104","article-title":"A Randomized, Controlled, Split\u2010Face Study of the Efficacy of a Picosecond Laser in the Treatment of Melasma","volume":"18","author":"Lyons A. B.","year":"2019","journal-title":"Journal of Drugs in Dermatology"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.10.051"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(81)70071-9"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2011.00517.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12684"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13484"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13298"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13434"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1132823"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23723"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.2.167"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22540"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.17091"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12348"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000197"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.70177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T13:42:55Z","timestamp":1756215775000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.70177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/srt.70177"],"URL":"https:\/\/doi.org\/10.1111\/srt.70177","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2024-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70177"}}