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Combined with intense year\u2010round ultraviolet exposure, this accelerates skin aging. Male skin also exhibits distinct aging characteristics. This study aims to evaluate the efficacy and safety of the Genistein Plus Bakuchiol and Vitamins (GEN\n                      <jats:sup>+<\/jats:sup>\n                      ) product on male facial skin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      A randomized, double\u2010blind, placebo\u2010controlled trial was conducted in men aged 45\u201365 years. Participants were assigned to receive either the GEN\n                      <jats:sup>+<\/jats:sup>\n                      or placebo (PLA) product in a 1:1 ratio and applied the product twice daily for 12 weeks. Facial skin assessments were performed at baseline and at weeks 4, 8, and 12. Evaluated parameters included skin color and consistency, spots, pigmentation, redness, acne, elasticity, hydration, barrier function, and wrinkles. Compliance and satisfaction were also monitored.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty male participants were enrolled (GEN\n                      <jats:sup>+<\/jats:sup>\n                      :\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a040; PLA:\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a040). After 12 weeks, the GEN\n                      <jats:sup>+<\/jats:sup>\n                      group demonstrated significant improvements in cheek skin lightening (MD = 0.55, 95% CI: 0.03 to 1.08,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.04) and color consistency (MD = \u20130.56, 95% CI: \u20131.06 to \u20130.06,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03), along with a reduction in forehead spots (MD = \u20130.60, 95% CI: \u20131.15 to \u20130.06,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03). No significant differences were observed in melanin\u2010, erythema\u2010, or acne\u2010related parameters. Skin property parameters did not differ significantly between groups, except for skin roughness. Adverse events were mild and self\u2010resolving. While satisfaction scores did not differ significantly, the GEN\n                      <jats:sup>+<\/jats:sup>\n                      group reported higher scores across most domains.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The GEN\n                      <jats:sup>+<\/jats:sup>\n                      product demonstrated promising improvements in male facial skin appearance, including skin lightening, color consistency, and spot reduction. The product was well\u2010tolerated and offered a safe, targeted skincare solution for men.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>ClinicalTrials.gov identifier: TCTR20240312001<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.70310","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T12:52:33Z","timestamp":1768999953000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Randomized Controlled Trial of the Genistein Plus Bakuchiol and Vitamins (GEN\n                    <sup>+<\/sup>\n                    ) Product for Male Facial Skin: Effects on Skin Appearance and 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