{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:03:24Z","timestamp":1791270204900,"version":"4.1.0"},"reference-count":82,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Acne is a prevalent dermatological disorder that profoundly affects patients' quality of life, frequently resulting in both physical discomfort and psychological distress. Conventional treatments, including topical agents, oral medications, and chemical peels, are primarily designed to alleviate symptoms but may be insufficient in effectively addressing persistent acne scars. Recent innovations in therapeutic technologies, such as microneedling radiofrequency (RF) and fractional carbon dioxide (CO\n                      <jats:sub>2<\/jats:sub>\n                      ) laser, have demonstrated significant potential in enhancing skin regeneration and improving the aesthetic appearance of acne scars.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Microneedling RF operates by generating mechanical microinjuries in conjunction with RF energy, thereby stimulating dermal remodeling and collagen synthesis. In contrast, fractional CO\n                      <jats:sub>2<\/jats:sub>\n                      laser creates precisely controlled microthermal zones that facilitate wound healing and promote the regeneration of new tissue. This review critically examines the clinical efficacy of these two modalities, exploring their individual mechanisms and comparing treatment outcomes. Additionally, the potential synergistic effects of combining these technologies are discussed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both microneedling RF and fractional CO\n                      <jats:sub>2<\/jats:sub>\n                      laser have demonstrated clinical efficacy in treating acne scars. The treatment outcomes, however, may vary depending on patient\u2010specific factors and treatment parameters. The combined use of these modalities is currently under investigation for its potential to enhance therapeutic effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Microneedling RF and fractional CO\n                      <jats:sub>2<\/jats:sub>\n                      laser have proven to be effective in improving acne scars, with promising results in skin regeneration and scar appearance. Future research should focus on refining treatment protocols and exploring the synergistic effects of combining these approaches to optimize clinical outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.70345","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T02:46:30Z","timestamp":1775184390000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Efficacy and Safety of Fractional CO\n                    <sub>2<\/sub>\n                    Laser and Gold Microneedling Radiofrequency for Atrophic Acne Scars: A Systematic Review"],"prefix":"10.1111","volume":"32","author":[{"given":"Xiaoyan","family":"Xiang","sequence":"first","affiliation":[{"name":"Department of Dermatology The Affiliated Hospital of North Sichuan Medical College  Nanchong Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilong","family":"Shuai","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Affiliated Hospital of North Sichuan Medical College  Nanchong Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunzhu","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Affiliated Hospital of North Sichuan Medical College  Nanchong Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"issue":"9","key":"e_1_2_13_2_1","first-page":"27","article-title":"The Role of Inflammation in the Pathology of Acne","volume":"6","author":"Tanghetti E. 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