{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:02:25Z","timestamp":1784872945192,"version":"3.55.0"},"reference-count":13,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Kyrle's disease is a rare skin disorder involving transepidermal keratin elimination, usually linked to systemic illness. We report a unique case\u2014a healthy 26\u2010year\u2010old man resistant to standard therapy. Remission was achieved with daily topical trifarotene 0.005% over eight weeks. This is the first reported KD case successfully treated with trifarotene, a selective RAR\u2010\u03b3 retinoid targeting keratinocyte differentiation and inflammation. Its efficacy and safety suggest promise for patients unsuitable for systemic therapy. A summary table of all topical treatment methods for Kyrle's disease, included in the article, provides valuable guidance for managing patients with significant comorbidities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.70359","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:36:41Z","timestamp":1784673401000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful Trifarotene Treatment of a Typical Kyrle's Disease With Overview of Topical Therapies"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5193-2074","authenticated-orcid":false,"given":"Wiktor","family":"Kruczek","sequence":"first","affiliation":[{"name":"Students\u2019 Scientific Association at the Department of Dermatology School of Medicine in Katowice Medical University of Silesia  Katowice Poland"},{"name":"Doctoral School Medical University of Silesia  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