{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:02:25Z","timestamp":1784872945099,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Skin prick tests(SPTs) are widely used diagnostic tests for evaluating type I hypersensitivity and are interpreted based on human\u2010measured wheal diameters. However, their diagnostic value may be limited by variability in application, measurement, and interpretation due to human dependency. Medical thermography offers a non\u2010invasive, objective, and quantitative method to assess local inflammatory responses. This study aimed to evaluate the feasibility and agreement of thermographic imaging for reading pediatric SPTs and to explore its potential role in supporting a more objective and standardized interpretation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In this cross\u2010sectional observational study, SPTs were performed on the upper backs of children aged 5\u201318 using a standardized aeroallergen panel, along with histamine and saline controls. Thermal images were captured at 0, 2, 5, 10, and 15 min using a mobile thermal camera. The Caloric Allergy Index(CAI) was established to quantify allergen\u2010induced skin warming relative to positive and negative controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Data from 63 pediatric patients were analyzed. Cohen's Kappa scores ranged from 0.432 to 0.838, indicating moderate to almost perfect agreement between CAI values and conventional wheal measurements. Allergens including grass mix(\n                      <jats:italic>\u03ba<\/jats:italic>\n                      = 0.838) and\n                      <jats:italic>C. dactylis<\/jats:italic>\n                      (\n                      <jats:italic>\u03ba<\/jats:italic>\n                      = 0.833) showed the highest agreement, followed by\n                      <jats:italic>D. pteronyssinus<\/jats:italic>\n                      (\n                      <jats:italic>\u03ba<\/jats:italic>\n                      = 0.753) and\n                      <jats:italic>D. farinae<\/jats:italic>\n                      (\n                      <jats:italic>\u03ba<\/jats:italic>\n                      = 0.672). Moderate agreement was observed for tree mix, cat, and dog epithelium. Positive test sites exhibited continuous warming, typically became statistically discernible in 2\u20135 min, while negative sites showed minimal change.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study introduces a thermographic parameter with overall agreement to conventional SPT readings, supporting the feasibility of thermography as a complementary objective approach in pediatric SPT interpretation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.70363","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:06:46Z","timestamp":1784286406000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thermographic Quantification of Skin Prick Test Responses in Children: The Caloric Allergy Index"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3276-748X","authenticated-orcid":false,"given":"Oguzhan","family":"Serin","sequence":"first","affiliation":[{"name":"Division of Pediatric Emergency, Department of Pediatrics Hacettepe University Medical School  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0543-1443","authenticated-orcid":false,"given":"Devrim","family":"Onder","sequence":"additional","affiliation":[{"name":"Infrared Software Research and Development Consultancy Engineering Ltd. Dokuz Eylul University Teknocity  Izmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0884-8079","authenticated-orcid":false,"given":"Umut Ece","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Health Research Hacettepe University Institute of Public Health  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0088-913X","authenticated-orcid":false,"given":"Umit M.","family":"Sahiner","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy, Department of Pediatrics Hacettepe University Medical School  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4232-3396","authenticated-orcid":false,"given":"Bulent E.","family":"Sekerel","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy, Department of Pediatrics Hacettepe University Medical School  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7444-251X","authenticated-orcid":false,"given":"Ozge","family":"Soyer","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy, Department of Pediatrics Hacettepe University Medical School  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-3-3"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2006.00388.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12921"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1993.tb02485.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.70039"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60305-5"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.infrared.2012.03.007"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2017-000080"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/s20051321"},{"issue":"3","key":"e_1_2_12_11_1","first-page":"102","article-title":"Are the IR Cameras FLIR ONE Suitable for Clinical Applications?","volume":"23","author":"Vardasca R.","year":"2019","journal-title":"Thermology International"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2018.12.001"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01363.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10973-016-5676-3"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10973-019-08814-4"},{"issue":"2","key":"e_1_2_12_16_1","first-page":"287","article-title":"Investigation of the Anti\u2010Allergic Activity of Azelastine on the Immediate and Late\u2010Phase Reactions to Allergens and Histamine Using Telethermography","volume":"30","author":"Weck D.","year":"2000","journal-title":"Clinical & Experimental Allergy"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12120"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.infrared.2015.02.007"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000003175"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.01.032"},{"key":"e_1_2_12_22_1","doi-asserted-by":"crossref","unstructured":"J. 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M.Verdaasdonk \u201cComparison of the Temperature Accuracy Between Smart Phone Based and High\u2010End Thermal Cameras Using a Temperature Gradient Phantom \u201d (International Society for Optics and Photonics 2017):100560D.","DOI":"10.1117\/12.2252898"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60220-7"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14843"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12300"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.04.056"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.3533940"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2016.60611"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(95)70136-2"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62776-7"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(93)90019-C"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.70363","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/srt.70363","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.70363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:19:00Z","timestamp":1784870340000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.70363"}},"subtitle":["Thermographic Analysis: Pediatric Skin Prick Tests"],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/srt.70363"],"URL":"https:\/\/doi.org\/10.1111\/srt.70363","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2024-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70363"}}