{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T08:33:29Z","timestamp":1793003609022,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The evaluation of facial corticosteroid addiction dermatitis (FCAD) lacks objective criteria, and existing clinical evaluation methods largely ignore regional facial heterogeneity. This study aimed to develop a site\u2010adjusted multimodal nomogram integrating 22\u2010MHz high\u2010frequency ultrasonography (HFUS) and transepidermal water loss (TEWL) to serve as an adjunctive quantitative assessment tool to quantify the FCAD pathological state objectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In this prospective case\u2010control study, 279 facial sites (119 lesional, 160 healthy) from 40 patients with FCAD and 40 healthy controls (HCs) were evaluated. Generalized estimating equations (GEE) were employed to adjust for the intra\u2010subject clustering effect of multisite data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multivariable GEE identified four independent predictors for FCAD: marked blood flow on power Doppler imaging (PDI) (adjusted odds ratio [aOR] = 19.46,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), subepidermal low\u2010echogenic band (SLEB) thickness (aOR = 1.76 per 0.01\u00a0mm increase,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.005), TEWL (aOR = 1.11,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002), and the chin site (vs. forehead, aOR = 0.35,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.009). The resulting nomogram achieved an area under the curve (AUC) of 0.905, significantly outperforming a single\u2010parameter vascular model (AUC = 0.821,\n                      <jats:italic>p &lt;<\/jats:italic>\n                      0.05). At the optimal probability cutoff, sensitivity was 85.7% and specificity was 86.9%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Integrating vascular, structural, and functional dimensions with anatomical site adjustments establishes a robust baseline for characterizing FCAD. This multimodal nomogram is intended for use as an adjunctive tool for quantitative assessment and disease monitoring, facilitating a critical shift from subjective clinical evaluation to precise, quantitative imaging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.70388","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:36:42Z","timestamp":1791805002000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Site\u2010Specific Characterization and Quantification of Facial Corticosteroid Addiction Dermatitis: A Multimodal Nomogram Integrating High\u2010Frequency Ultrasonography and Transepidermal Water Loss"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7563-5461","authenticated-orcid":false,"given":"Jun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Nanxiang Branch Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8459-3192","authenticated-orcid":false,"given":"Ji Tao","family":"Gui","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Nanxiang Branch Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7743-4296","authenticated-orcid":false,"given":"Rong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Nanxiang Branch Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8467-7206","authenticated-orcid":false,"given":"Hai Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ruijin Hospital, Nanxiang Branch Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7454-8326","authenticated-orcid":false,"given":"Yang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ruijin Hospital, Nanxiang Branch Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0009-7186","authenticated-orcid":false,"given":"Ting","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ruijin Hospital, Nanxiang Branch Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102230.2009.03761.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.11.024"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2025.1547923"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346\u20108138.12877"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.25259\/ijdvl_11_2020"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2196\/57687"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13050970"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13089\u2010021\u201000222\u2010w"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2024.0148"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12562"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13219"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"issue":"8","key":"e_1_2_11_14_1","first-page":"549","article-title":"The Subspecialty Group of Cosmetic Dermatology of Chinese Medical Doctor Association. 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