{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:51:35Z","timestamp":1791888695096,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n High\u2010intensity focused ultrasound (HIFU) is widely used for noninvasive eyebrow lifting, but within\u2010subject comparisons of cartridge focal depths are scarce.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To evaluate the efficacy and safety of 1.5\u2010 and 3.0\u2010mm cartridges for eyebrow lifting in Korean adults, with an exploratory between\u2010depth comparison.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In this randomized split\u2010face study, 20 Korean adults were treated once with the 1.5\u2010mm cartridge on one side and the 3.0\u2010mm contralaterally (225 J\/side). Average and maximum eyebrow heights (AEH, primary; MEH, secondary) were measured from standardized photographs at baseline, post\u2010treatment, and weeks 1, 4, and 12. Satisfaction, pain, and adverse events were recorded.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Both measures increased significantly at all time points (unadjusted\n p<\/jats:italic>\n < 0.05). At week 12, AEH increased by 1.76 \u00b1 1.19\u00a0mm (1.5\u2010mm) and 1.23 \u00b1 1.33\u00a0mm (3.0\u2010mm); 98.75% one\u2010sided CI lower bounds (1.10 and 0.51\u00a0mm) met the corrected primary efficacy criterion. MEH met the separately corrected criterion with the 1.5\u2010mm (0.57\u00a0mm) but not the 3.0\u2010mm cartridge (\u22120.08\u00a0mm). The exploratory week\u201012 AEH difference was nonsignificant (\n p<\/jats:italic>\n = 0.116). No treatment\u2010related adverse events occurred over 12 weeks, supporting short\u2010term tolerability in this cohort rather than definitive safety.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Each cartridge was associated with significant within\u2010subject increases in photographic eyebrow\u2010height measures through 12 weeks and high satisfaction, although the corrected MEH criterion was not met with the 3.0\u2010mm cartridge. Without a sham control, findings indicate within\u2010subject improvement, not causal efficacy; the between\u2010cartridge comparison is inconclusive, not evidence of equivalence. Larger, sham\u2010controlled studies are needed.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/srt.70393","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:29:01Z","timestamp":1791887341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of 1.5\u2010 and 3.0\u2010mm High\u2010Intensity Focused Ultrasound for Eyebrow Lifting in Korean Adults: A Prospective Randomized Split\u2010Face Study"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0137-6849","authenticated-orcid":false,"given":"Kwang Ho","family":"Yoo","sequence":"first","affiliation":[{"name":"Department of Dermatology Chung\u2010Ang University Gwangmyeong Hospital Chung\u2010Ang University College of Medicine Gwangmyeong\u2010si Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyewon","family":"Song","sequence":"additional","affiliation":[{"name":"Clinical & Academic Affairs Eunsung Global Co., Ltd. Wonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhwa","family":"Choi","sequence":"additional","affiliation":[{"name":"Clinical & Academic Affairs Eunsung Global Co., Ltd. Wonju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"issue":"2","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.5021\/ad.2019.31.2.223","article-title":"Effect of High\u2010Intensity Focused Ultrasound on Eyebrow Lifting in Asians","volume":"31","author":"Oh W. J.","year":"2019","journal-title":"Ann Dermatol"},{"issue":"3","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/jocd.12106","article-title":"Patient Selection for Skin\u2010Tightening Procedures","volume":"13","author":"Northington M.","year":"2014","journal-title":"Journal of Cosmetic Dermatology"},{"issue":"5","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/s10103-020-02957-9","article-title":"Systematic Review and Meta\u2010Analysis of Safety and Efficacy of High\u2010Intensity Focused Ultrasound (HIFU) for Face and Neck Rejuvenation","volume":"35","author":"Ayatollahi A.","year":"2020","journal-title":"Lasers in Medical Science"},{"issue":"6","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3390\/cosmetics9060116","article-title":"Expert Opinion on Non\u2010Surgical Eyebrow Lifting and Shaping Procedures","volume":"9","author":"Omran D.","year":"2022","journal-title":"Cosmetics"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.06.039"},{"issue":"4","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.25289\/ML.25.025","article-title":"Comparison of Two Microfocused Ultrasound Treatment Protocols for Eyebrow Lifting in a Korean Female Cohort in Republic of Korea: A Split\u2010Face Clinical Study","volume":"14","author":"Choi J. H.","year":"2025","journal-title":"Medical Lasers"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20021522"},{"issue":"1","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10103-025-04331-z","article-title":"Efficacy and Safety of Microfocused Ultrasound for Temporary Eyebrow Lift and Glabellar Wrinkle Reduction","volume":"40","author":"Choi E. J.","year":"2025","journal-title":"Lasers in Medical Science"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjaf053"},{"issue":"12","key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"3942","DOI":"10.1111\/jocd.16482","article-title":"Ultrasound Rejuvenation for Upper Facial Skin: A Randomized Blinded Prospective Study","volume":"23","author":"Chen W.","year":"2024","journal-title":"Journal of Cosmetic Dermatology"},{"issue":"8","key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1111\/jocd.13550","article-title":"The Efficacy of Macro\u2010Focused Ultrasound in the Treatment of Upper Facial Laxity: A Pilot Study","volume":"19","author":"Wanitphakdeedecha R.","year":"2020","journal-title":"Journal of Cosmetic Dermatology"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S350556"},{"issue":"4","key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.fsc.2023.05.008","article-title":"Ultrasound Therapy for the Skin","volume":"31","author":"Wong A.","year":"2023","journal-title":"Facial Plastic Surgery Clinics of North America"},{"issue":"4","key":"e_1_2_10_15_1","first-page":"341","article-title":"Simulation Study on the Effect of HIFU Irradiation Frequency and Duty Cycle Combination Parameter Optimization on Thermal Lesion of Biological Tissue","volume":"15","author":"Dong H.","year":"2025","journal-title":"Journal of Biomedical Physics and Engineering"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.70393","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/srt.70393","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.70393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:29:03Z","timestamp":1791887343000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.70393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/srt.70393"],"URL":"https:\/\/doi.org\/10.1111\/srt.70393","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70393"}}