{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:47:55Z","timestamp":1791809275450,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Electromagnetic transduction therapy (EMTT) is a high\u2010intensity pulsed electromagnetic field therapy used in musculoskeletal medicine. However, its therapeutic effects on human dermal fibroblasts (HDFs) remain unclear. Secretomes from human dermal fibroblast\u2010conditioned medium (HDFCM) can enhance wound repair and tissue regeneration.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Young and aged HDFs were treated with EMTT (40 or 80 mT) following HDFCM pretreatment (0, 30, or 60%). Proliferation and migration were assessed using cell proliferation and wound healing assays. Senescence\u2010associated \u03b2\u2010galactosidase (SA\u2010\u03b2\u2010Gal) staining and enzyme\u2010linked immunosorbent assay (ELISA) were performed to evaluate the effects of EMTT and HDFCM on senescence and pro\u2010 and anti\u2010inflammatory cytokine secretion.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n HDFCM significantly enhanced the proliferation of young and aged HDFs, particularly aged cells, in a dose\u2010dependent manner. EMTT at 40 mT further enhanced these effects, with 40 mT EMTT plus 30% HDFCM yielding the greatest increase in the number of aged HDF. SA\u2010\u03b2\u2010Gal activity, minimal in young cells, was elevated in aged HDFs, but was reduced by 40 mT EMTT with or without HDFCM. Contrastingly, 80 mT EMTT increased SA\u2010\u03b2\u2010Gal activity unless counteracted by 60% HDFCM. Moreover, interleukin\u20106 was upregulated and transforming growth factor\u2010\u03b2 was downregulated by HDFCM and EMTT treatments.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n EMTT at low magnetic field strength, particularly if combined with HDFCM, promotes proliferation and migration while reducing senescence in aged HDFs. This approach may offer a promising therapeutic strategy for skin regeneration and antiaging applications, especially for aging or damaged dermal tissues.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/srt.70394","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:15:07Z","timestamp":1791807307000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Dermal Fibroblast\u2010Conditioned Media on Human Dermal Fibroblasts Treated With Electromagnetic Transduction Therapy"],"prefix":"10.1111","volume":"32","author":[{"given":"Jeongah","family":"Ko","sequence":"first","affiliation":[{"name":"Ko Jung A Clinic Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Bum","family":"Suh","sequence":"additional","affiliation":[{"name":"BNV Biolab Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong Ju","family":"Oh","sequence":"additional","affiliation":[{"name":"BNV Biolab Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Youn","family":"Suh","sequence":"additional","affiliation":[{"name":"BNV Biolab Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Bin","family":"Cho","sequence":"additional","affiliation":[{"name":"Yonsei Seran Dermatology and Laser Clinic Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1080\/15368378.2022.2079672","article-title":"Stimulation of Human Bone Marrow Mesenchymal Stem Cells by Electromagnetic Transduction Therapy\u2014EMTT","volume":"41","author":"Gerdesmeyer L.","year":"2022","journal-title":"Electromagnetic Biology and Medicine"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0091581","article-title":"A Novel Single Pulsed Electromagnetic Field Stimulates Osteogenesis of Bone Marrow Mesenchymal Stem Cells and Bone Repair","volume":"9","author":"Fu Y. 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