{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:38:33Z","timestamp":1792827513744,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:00:00Z","timestamp":1792800000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Photobiomodulation has gained considerable attention for its potential in various dermatological applications. We assessed the anti\u2010aging effects of a home\u2010use face\u2010fit mask combining 630 and 850\u00a0nm light\u2010emitting diodes (LEDs) and an anti\u2010aging cream in\n ex vivo<\/jats:italic>\n and prospective exploratory clinical studies. Both products are commercially available.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Skin samples from six\u00a0women aged 39\u250055\u00a0years were either left untreated or received topical treatments for 7\u00a0days: LED irradiation (7\u2010minute sessions) or cream (2\u00a0mg\/cm\n 2<\/jats:sup>\n ), or both. In the clinical study, women aged 49\u250065\u00a0years (\n n<\/jats:italic>\n = 50) applied the cream daily to the face and neck for 56\u00a0days and used the mask 3\u25004\u00a0times per week.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Compared to untreated skin samples, the combination of LEDs and cream increased the expression of elastin (+29.6%) and collagen\u00a01 (+7.6%) (\n p<\/jats:italic>\n <\u00a00.05 for both). The expression of elastin also increased following treatment with the LEDs alone (+26.1%;\n p<\/jats:italic>\n <\u00a00.05). the effect of LEDs and cream combined treatment was demonstrated on collagen\u00a01 expression, with a similar trend observed for elastin expression. In the clinical study, investigator\u2010assessed clinical scores showed significant progressive improvements from baseline, reaching +57.1% for skin radiance, \u201039.4% for pore dilatation, and \u201024.2% for crow's feet wrinkle depth at Day\u00a056 (\n p<\/jats:italic>\n <\u00a00.0001 for all). Participants also perceived significantly improved skin radiance and smoothing of face and neck wrinkles throughout the study.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The LED mask and the anti\u2010aging cream led to visible and clinically measurable skin signs of ageing reduction versus baseline. The increase in collagen I and elastin expression observed in the ex vivo study could contribute to the visible reduction in signs of aging demonstrated in the clinical study.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/srt.70395","type":"journal-article","created":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:14:53Z","timestamp":1792826093000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2010Aging Efficacy of a Home\u2010use red and Infrared Light\u2010Emitting Diode Mask and a Cream: Ex Vivo and Clinical Evaluations in Women With Mature Skin"],"prefix":"10.1111","volume":"32","author":[{"given":"Aurore","family":"Bellanger","sequence":"first","affiliation":[{"name":"Laboratoires Pontoise France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Gu\u00e9r\u00e9","sequence":"additional","affiliation":[{"name":"Laboratoires Pontoise France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Boisnic","sequence":"additional","affiliation":[{"name":"Gredeco Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doroth\u00e9e","family":"Godet","sequence":"additional","affiliation":[{"name":"Laboratoires Pontoise France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,24]]},"reference":[{"issue":"3","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jdermsci.2016.09.015","article-title":"The Skin Aging Exposome","volume":"85","author":"Krutmann J.","year":"2017","journal-title":"Journal of Dermatological Science"},{"issue":"5","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1177\/0963689717725755","article-title":"Fighting Against Skin Aging: The way From Bench to Bedside","volume":"27","author":"Zhang S.","year":"2018","journal-title":"Cell Transplantation"},{"issue":"4","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.det.2005.05.012","article-title":"Psychosocial Aspects of Aging Skin","volume":"23","author":"Gupta M. A.","year":"2005","journal-title":"Dermatologic Clinics"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.2147\/CCID.S449599","article-title":"Development of Home Beauty Devices for Facial Rejuvenation: Establishment of Efficacy Evaluation System","volume":"17","author":"Bu P.","year":"2024","journal-title":"Clinical, Cosmetic and Investigational Dermatology"},{"issue":"1","key":"e_1_2_11_6_1","first-page":"41","article-title":"Low\u2010Level Laser (light) Therapy (LLLT) in Skin: Stimulating, Healing, Restoring","volume":"32","author":"Avci P.","year":"2013","journal-title":"Seminars in Cutaneous Medicine and Surgery"},{"issue":"2","key":"e_1_2_11_7_1","first-page":"21","article-title":"Phototherapy With Light Emitting Diodes: Treating a Broad Range of Medical and Aesthetic Conditions in Dermatology","volume":"11","author":"Ablon G.","year":"2018","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"issue":"4","key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.36849\/JDD.2020.4711","article-title":"Light Emitting Diode Phototherapy for Skin Aging","volume":"19","author":"Huang A.","year":"2020","journal-title":"Journal of Drugs in Dermatology: JDD"},{"issue":"8","key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.3390\/ijms25084483","article-title":"Unlocking the Power of Light on the Skin: A Comprehensive Review on Photobiomodulation","volume":"25","author":"Hern\u00e1ndez\u2010Bule M. L.","year":"2024","journal-title":"International Journal of Molecular Sciences"},{"issue":"6","key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/lsm.22791","article-title":"Light\u2010Emitting Diodes in Dermatology: A Systematic Review of Randomized Controlled Trials","volume":"50","author":"Jagdeo J.","year":"2018","journal-title":"Lasers in Surgery and Medicine"},{"issue":"1","key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s10103-024-04018-x","article-title":"A Study of the Biological Effects of Low\u2010Level Light","volume":"39","author":"Zhang F.","year":"2024","journal-title":"Lasers in Medical Science"},{"issue":"4","key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.sder.2008.08.003","article-title":"Light\u2010Emitting Diodes (LEDs) in Dermatology","volume":"27","author":"Barolet D.","year":"2008","journal-title":"Seminars in Cutaneous Medicine and Surgery"},{"issue":"4","key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/phpp.12841","article-title":"Utilization of Light\u2010Emitting Diodes for Skin Therapy: Systematic Review and Meta\u2010Analysis","volume":"39","author":"Ngoc L. T. N.","year":"2023","journal-title":"Photodermatology, Photoimmunology & Photomedicine"},{"issue":"18001","key":"e_1_2_11_14_1","first-page":"A1","article-title":"Efficacit\u00e9 d'un Masque LED Home use Combinant Deux Longueurs D'ondes (630 et 850\u00a0nm) sur Les Signes de Vieillissement Cutan\u00e9","volume":"8062","author":"Bellanger A.","year":"2023","journal-title":"Annales de Dermatologie et de V\u00e9n\u00e9r\u00e9ologie\u2014FMC"},{"key":"e_1_2_11_15_1","unstructured":"R.BazinandE.Doublet \u201cAtlas Du Vieillissement Cutan\u00e9 tome 1. Population Europ\u00e9enne: \u00c9ditions Med'Com \u201d (2007)."},{"issue":"3","key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/ics.12698","article-title":"Low\u2010Level red Plus Near Infrared Lights Combination Induces Expressions of Collagen and Elastin in Human Skin in Vitro","volume":"43","author":"Li W. H.","year":"2021","journal-title":"International Journal of Cosmetic Science"},{"issue":"2","key":"e_1_2_11_17_1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3892\/ijmm.2014.2030","article-title":"Continuous Irradiation With a 633\u2010nm Light\u2010Emitting Diode Exerts an Anti\u2010Aging Effect on Human Skin Cells","volume":"35","author":"Kim H. S.","year":"2015","journal-title":"International Journal of Molecular Medicine"},{"issue":"12","key":"e_1_2_11_18_1","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1038\/jid.2009.186","article-title":"Regulation of Skin Collagen Metabolism in Vitro Using a Pulsed 660 Nm LED Light Source: Clinical Correlation With a Single\u2010Blinded Study","volume":"129","author":"Barolet D.","year":"2009","journal-title":"Journal of Investigative Dermatology"},{"issue":"1","key":"e_1_2_11_19_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.22467\/jwmr.2018.00283","article-title":"Effect of Low\u2010Level Laser Therapy on Proliferation and Collagen Synthesis of Human Fibroblasts in Vitro","volume":"14","author":"Ma H.","year":"2018","journal-title":"Journal of Wound Management and Research"},{"issue":"1","key":"e_1_2_11_20_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jphotobiol.2007.04.008","article-title":"A Prospective, Randomized, Placebo\u2010Controlled, Double\u2010Blinded, and Split\u2010Face Clinical Study on LED Phototherapy for Skin Rejuvenation: Clinical, Profilometric, Histologic, Ultrastructural, and Biochemical Evaluations and Comparison of Three Different Treatment Settings","volume":"88","author":"Lee S. Y.","year":"2007","journal-title":"Journal of Photochemistry and Photobiology B Biology"},{"issue":"8","key":"e_1_2_11_21_1","first-page":"748","article-title":"Combined 633\u2010nm and 830\u2010nm Led Treatment of Photoaging Skin","volume":"5","author":"Goldberg D. J.","year":"2006","journal-title":"Journal of Drugs in Dermatology: JDD"},{"issue":"12","key":"e_1_2_11_22_1","doi-asserted-by":"crossref","DOI":"10.1002\/jbio.202000230","article-title":"Safety and Efficacy of a Novel Home\u2010Use Device for Light\u2010potentiated (LED) Skin Treatment","volume":"13","author":"Guermonprez C.","year":"2020","journal-title":"Journal of Biophotonics"},{"issue":"2","key":"e_1_2_11_23_1","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14054","article-title":"Aging in the Dermis: Fibroblast Senescence and Its Significance","volume":"23","author":"Zhang J.","year":"2024","journal-title":"Aging Cell"},{"issue":"3","key":"e_1_2_11_24_1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1080\/14764170500370059","article-title":"A Study to Determine the Efficacy of Combination LED Light Therapy (633\u00a0nm and 830\u00a0nm) in Facial Skin Rejuvenation","volume":"7","author":"Russell B. 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H.","year":"2017","journal-title":"Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery"},{"issue":"7","key":"e_1_2_11_26_1","doi-asserted-by":"crossref","DOI":"10.1111\/srt.13391","article-title":"Reverse Skin Aging Signs by red Light Photobiomodulation","volume":"29","author":"Couturaud V.","year":"2023","journal-title":"Skin Research and Technology: Official Journal of International Society for Bioengineering and the Skin [And] International Society for Digital Imaging of Skin [And] International Society for Skin Imaging"},{"issue":"1","key":"e_1_2_11_27_1","doi-asserted-by":"crossref","DOI":"10.1111\/jocd.16599","article-title":"Efficacy and Safety of a Home\u2010Use Light\u2010Emitting Diode Neck Device for Improvement in Neck Wrinkles: A Multicenter, Randomized, Double\u2010Blind, Sham Device, Superiority Verification, Confirmatory Clinical Trial","volume":"24","author":"Park S. O.","year":"2025","journal-title":"Journal of Cosmetic Dermatology"},{"issue":"9","key":"e_1_2_11_28_1","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1111\/jocd.13613","article-title":"Efficacy of Home\u2010Use Light\u2010Emitting Diode Device at 637 and 854\u2010nm for Facial Rejuvenation: A Split\u2010Face Pilot Study","volume":"19","author":"Ng J. N. C.","year":"2020","journal-title":"Journal of Cosmetic Dermatology"},{"issue":"3","key":"e_1_2_11_29_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1473-2165.2007.00329.x","article-title":"The use of Light\u2010Emitting Diode Therapy in the Treatment of Photoaged Skin","volume":"6","author":"Baez F.","year":"2007","journal-title":"Journal of Cosmetic Dermatology"},{"issue":"6","key":"e_1_2_11_30_1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3390\/cosmetics12060273","article-title":"Evaluating Efficacy and Tolerability of a new Intradermal Biorejuvenation With Free Hyaluronic Acid and Glycerol in Photoaging: A Retrospective Pilot Study","volume":"12","author":"Trovato F.","year":"2025","journal-title":"Cosmetics"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.70395","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/srt.70395","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.70395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:14:57Z","timestamp":1792826097000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.70395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/srt.70395"],"URL":"https:\/\/doi.org\/10.1111\/srt.70395","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70395"}}