{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:19:31Z","timestamp":1790266771591,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,10,18]],"date-time":"2012-10-18T00:00:00Z","timestamp":1350518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tissue Antigens"],"published-print":{"date-parts":[[2012,12]]},"abstract":"Homozygosity for a nonsense mutation in the fucosyltransferase 2 (FUT2<\/jats:styled-content><\/jats:italic>) gene (rs601338G<\/jats:styled-content>>A) leads to the absence of ABH<\/jats:styled-content> blood groups (FUT2<\/jats:styled-content> non\u2010secretor status) in body fluids. As the secretor status has been shown to be a major determinant for the gut microbial spectrum, assumed to be important in the gut immune homeostasis, we studied the association of rs601338\u2010FUT2<\/jats:styled-content><\/jats:italic> with celiac disease (CelD<\/jats:styled-content>) and inflammatory bowel disease (IBD<\/jats:styled-content>) in the Finnish population. Rs601338 was genotyped in CelD<\/jats:styled-content> (n<\/jats:italic>\u2009=\u2009909), dermatitis herpetiformis (DH<\/jats:styled-content>) (n<\/jats:italic>\u2009=\u2009116), ulcerative colitis (UC<\/jats:styled-content>) (n<\/jats:italic>\u2009=\u2009496) and Crohn's disease (CD<\/jats:styled-content>) (n<\/jats:italic>\u2009=\u2009280) patients and healthy controls (n<\/jats:italic>\u2009=\u20092738). CelD<\/jats:styled-content> showed significant genotypic [P<\/jats:italic>\u2009=\u20090.0074, odds ratio (OR<\/jats:styled-content>): 1.28] and recessive (P<\/jats:italic>\u2009=\u20090.015, OR<\/jats:styled-content>: 1.28) association with the rs601338\u2010AA<\/jats:styled-content> genotype. This was also found in the combined CelD<\/jats:styled-content>+DH<\/jats:styled-content> dataset (genotype association: P<\/jats:italic>\u2009=\u20090.0060, OR<\/jats:styled-content>: 1.28; recessive association: P<\/jats:italic>\u2009<\u20090.011, OR<\/jats:styled-content>: 1.28). The A allele of rs601338 showed nominal association with dominant protection from UC<\/jats:styled-content> (P<\/jats:italic>\u2009=\u20090.044, OR<\/jats:styled-content>: 0.82) and UC<\/jats:styled-content>+CD<\/jats:styled-content> (P<\/jats:italic>\u2009=\u20090.035, OR<\/jats:styled-content>: 0.84). The frequency of non\u2010secretors (rs601338\u2010GG<\/jats:styled-content>) in controls, CelD<\/jats:styled-content>, DH<\/jats:styled-content>, UC<\/jats:styled-content> and CD<\/jats:styled-content> datasets was 14.7%, 18%, 18.1%, 14.3% and 16.1%, respectively. No association was evident in the DH<\/jats:styled-content> or CD<\/jats:styled-content> datasets alone. In conclusion, FUT2<\/jats:styled-content> non\u2010secretor status is associated with CelD<\/jats:styled-content> susceptibility and FUT2<\/jats:styled-content> secretor status may also play a role in IBD<\/jats:styled-content> in the Finnish population.<\/jats:p>","DOI":"10.1111\/tan.12016","type":"journal-article","created":{"date-parts":[[2012,10,18]],"date-time":"2012-10-18T18:39:56Z","timestamp":1350585596000},"page":"488-493","source":"Crossref","is-referenced-by-count":96,"title":["Association study of FUT2<\/scp><\/i> (rs601338) with celiac disease and inflammatory bowel disease in the Finnish population"],"prefix":"10.1111","volume":"80","author":[{"given":"A. S.","family":"Parmar","sequence":"first","affiliation":[{"name":"Research Program for Molecular Medicine and Department of Medical Genetics Haartman Institute, University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Alakulppi","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Paavola\u2010Sakki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Kurppa","sequence":"additional","affiliation":[{"name":"Pediatric Research Center University of Tampere and Tampere University Hospital Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Halme","sequence":"additional","affiliation":[{"name":"Department of Surgery 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