{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T02:04:54Z","timestamp":1787969094614,"version":"build-2784847793"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T00:00:00Z","timestamp":1358726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tissue Antigens"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A meta\u2010analysis was performed to assess the association of the human leukocyte antigen\u2010G (<jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010G<\/jats:italic>) 14\u2009bp insertion (ins)\/deletion (del) polymorphism with unexplained recurrent spontaneous abortions (<jats:styled-content style=\"fixed-case\">URSA<\/jats:styled-content>). The fixed or random effect pooled measure was selected based on the homogeneity test among studies that was evaluated with <jats:italic><jats:styled-content style=\"fixed-case\">I<\/jats:styled-content><\/jats:italic><jats:sup>2<\/jats:sup>. Odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) with 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) was used to assess the strength of the association. In this meta\u2010analysis, 14 studies with 1464 cases and 1247 controls corresponded to the inclusion criteria were included. Significant associations between 14\u2009bp ins\/del polymorphism and risk of <jats:styled-content style=\"fixed-case\">URSA<\/jats:styled-content> were observed in both dominant [random effect model (<jats:styled-content style=\"fixed-case\">REM<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2009=\u20091.469, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u2009=\u20091.127\u20131.914] and codominant (<jats:styled-content style=\"fixed-case\">REM OR<\/jats:styled-content>\u2009=\u20091.195, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u2009=\u20091.005\u20131.420) models. After excluding two articles that deviated from Hardy\u2013Weinberg equilibrium in cases and sensitivity analysis, significant associations were also observed in dominant [fixed effect model (<jats:styled-content style=\"fixed-case\">FEM<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2009=\u20091.224, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u2009=\u20091.020\u20131.470] and codominant (<jats:styled-content style=\"fixed-case\">FEM OR<\/jats:styled-content>\u2009=\u20091.158, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u2009=\u20091.028\u20131.305) models. This meta\u2010analysis suggests that the 14\u2009bp ins <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010G<\/jats:italic> allele is associated with increased risk of <jats:styled-content style=\"fixed-case\">URSA<\/jats:styled-content>. The results are of importance to the clinical practice of <jats:styled-content style=\"fixed-case\">URSA<\/jats:styled-content> and infertility.<\/jats:p>","DOI":"10.1111\/tan.12056","type":"journal-article","created":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T10:41:26Z","timestamp":1358764886000},"page":"108-115","source":"Crossref","is-referenced-by-count":50,"title":["Association of 14\u2010bp insertion\/deletion polymorphism of <i><scp>HLA<\/scp>\u2010G<\/i> gene with unexplained recurrent spontaneous abortion: a meta\u2010analysis"],"prefix":"10.1111","volume":"81","author":[{"given":"X.","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Public Health Qingdao University Medical College  266021 Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Public Health Qingdao University Medical College  266021 Qingdao 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