{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:12:08Z","timestamp":1791321128378,"version":"4.3.1"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T00:00:00Z","timestamp":1381881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tissue Antigens"],"published-print":{"date-parts":[[2013,11]]},"abstract":"Abstract<\/jats:title>The aim of this study was to investigate the HLA<\/jats:styled-content>\u2010G<\/jats:italic> 14\u2010bp insertion\/deletion (I\/D) polymorphism among end\u2010stage renal disease (ESRD<\/jats:styled-content>) patients. Cytomegalovirus (CMV<\/jats:styled-content>) infection, acute allograft rejection (AR<\/jats:styled-content>) and overall survival after renal transplantation was investigated in 300 ESRD<\/jats:styled-content> patients and 302 age, sex and ethnicity\u2010matched controls. Sequencing was performed to evaluate the impact of HLA<\/jats:styled-content>\u2010G<\/jats:italic> promoter region single\u2010nucleotide polymorphisms (SNPs<\/jats:styled-content>) whereas semi\u2010quantitative PCR<\/jats:styled-content> method was used to determine the probable HLA<\/jats:styled-content>\u2010G<\/jats:italic> expression pattern among ESRD<\/jats:styled-content> and AR<\/jats:styled-content> cases. Further, soluble human leukocyte antigen (HLA<\/jats:styled-content>)\u2010G (sHLA<\/jats:styled-content>\u2010G) expression levels were compared in AR<\/jats:styled-content> vs<\/jats:italic> non\u2010AR<\/jats:styled-content> cases in the light of HLA<\/jats:styled-content>\u2010G<\/jats:italic> 14\u2010bp I\/D polymorphism. Increased risk was found for 14\u2010bp D\/D (deletion\u2010DD<\/jats:styled-content>) genotype and 14\u2010bp D allele [DD<\/jats:styled-content>: odds ratio (OR<\/jats:styled-content>)\u2009=\u20091.46, 95% confidence interval (CI<\/jats:styled-content>)\u2009=\u20091.03\u20132.06, P<\/jats:italic> value\u2009=\u20090.0358; D: OR<\/jats:styled-content>\u2009=\u20091.29, 95% CI<\/jats:styled-content>\u2009=\u20091.03\u20131.62, P<\/jats:italic> value\u2009=\u20090.0277], respectively for ESRD<\/jats:styled-content> and CMV<\/jats:styled-content> infection (DD<\/jats:styled-content>: OR<\/jats:styled-content>\u2009=\u20092.70, 95% CI<\/jats:styled-content>\u2009=\u20091.45\u20135.05, P<\/jats:italic> value\u2009=\u20090.0021; D: OR<\/jats:styled-content>\u2009=\u20091.94, 95% CI<\/jats:styled-content>\u2009=\u20091.22\u20133.08, P<\/jats:italic> value\u2009=\u20090.0052). Nearly fourfold (OR<\/jats:styled-content> = 3.62, 95%CI<\/jats:styled-content>\u2009=\u20091.61\u20108.14, p\u2009=\u20090.0039) risk was observed for 14\u2010bp I\/I (insertion\u2010II<\/jats:styled-content>) genotype for AR<\/jats:styled-content>. Survival analysis showed increased overall survival (OS) (AR<\/jats:styled-content> or death) for 14\u2010bp D\/D genotype. HLA<\/jats:styled-content>\u2010G<\/jats:italic> promoter region sequencing was carried out among 60 ESRD<\/jats:styled-content> patients and 100 normal controls which showed increased risk for \u2212964 G>A, \u2212725 C>G\/T and \u2212486 A>C SNPs<\/jats:styled-content>. \u2212964 G>A and \u2212725 C>G\/T SNPs<\/jats:styled-content> showed risk association for AR<\/jats:styled-content> patients. High level of HLA<\/jats:styled-content>\u2010G transcripts was observed among non\u2010AR<\/jats:styled-content> patients. Further soluble HLA<\/jats:styled-content>\u2010G (sHLA<\/jats:styled-content>\u2010G) showed increased levels in ESRD<\/jats:styled-content> patients (mean\u2009\u00b1\u2009SEM<\/jats:styled-content>; 62.16\u2009\u00b1\u20092.43\u2009U\/ml) as compared to controls (mean\u2009\u00b1\u2009SEM<\/jats:styled-content>; 21.06\u2009\u00b1\u20093.89\u2009U\/ml) (P<\/jats:italic>\u2009=\u2009<0.0001). The 14\u2010bp I\/I, 14\u2010bp I\/D and 14\u2010bp D\/D genotypes showed significantly higher levels of sHLA<\/jats:styled-content>\u2010G among non\u2010AR<\/jats:styled-content> as compared to AR<\/jats:styled-content> patients.<\/jats:p>","DOI":"10.1111\/tan.12210","type":"journal-article","created":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T21:23:29Z","timestamp":1381958609000},"page":"317-326","source":"Crossref","is-referenced-by-count":40,"title":["Association of HLA<\/scp>\u2010G promoter and 14\u2010bp insertion\u2013deletion variants with acute allograft rejection and end\u2010stage renal disease"],"prefix":"10.1111","volume":"82","author":[{"given":"M. K.","family":"Misra","sequence":"first","affiliation":[{"name":"Department of Medical genetics Sanjay Gandhi Post\u2010graduate Institute of Medical Sciences Lucknow India"},{"name":"Department of Anatomy, Institute of Medical Sciences Banaras Hindu University Varanasi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Prakash","sequence":"additional","affiliation":[{"name":"Department of Medical genetics Sanjay Gandhi Post\u2010graduate Institute of Medical Sciences Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Department of Urology and Renal Transplantation Sanjay Gandhi Post\u2010graduate Institute of Medical Sciences Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. K.","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Institute of Medical Sciences Banaras Hindu University Varanasi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. K.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Nephrology Sanjay Gandhi Post\u2010graduate Institute of Medical Sciences Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Medical genetics Sanjay Gandhi Post\u2010graduate Institute of Medical Sciences Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912023412303"},{"key":"e_1_2_8_3_1","unstructured":"WolfeRA AshbyVB MilfordELet al. 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