{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T18:46:26Z","timestamp":1724352386081},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T00:00:00Z","timestamp":1385078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tissue Antigens"],"published-print":{"date-parts":[[2013,12]]},"abstract":"Abstract<\/jats:title>Human leukocyte antigen (HLA<\/jats:styled-content>)\u2010B27<\/jats:styled-content> is the mostly known major histocompatibility complex (MHC<\/jats:styled-content>) gene associated with ankylosing spondylitis (AS<\/jats:styled-content>). Nonetheless, there is substantial evidence that other MHC<\/jats:styled-content> genes appear to be associated with the disease, although it has not yet been established whether these associations are driven by direct associations or by linkage disequilibrium (LD<\/jats:styled-content>) mechanisms. We aimed to investigate the contributions of HLA<\/jats:styled-content> class I and II<\/jats:styled-content> alleles and B27<\/jats:styled-content>\u2010haplotypes for AS<\/jats:styled-content> in a case\u2013control study. A total of 188 HLA\u2010B27 AS<\/jats:styled-content> cases and 189 HLA\u2010B27<\/jats:styled-content> healthy controls were selected and typed for HLA<\/jats:styled-content> class I and II<\/jats:styled-content> by the Luminex polymerase chain reaction\u2010sequence specific oligonucleotide probe (PCR\u2010SSOP<\/jats:styled-content>) method. Allelic and haplotypic distributions were estimated by maximum likelihood method using Arlequin v3.11 and statistical analysis were performed by Stata10.1. No associations were found between non\u2010HLA\u2010B27<\/jats:styled-content> loci and AS<\/jats:styled-content> susceptibility, but several associations were observed for phenotypic features of the disease. DRB1<\/jats:italic><\/jats:styled-content>*08<\/jats:italic> was identified as a risk factor for uveitis and DQB1<\/jats:italic><\/jats:styled-content>*04<\/jats:italic> seems to provide protection for AS<\/jats:styled-content> severity (functional, metrological and radiological indexes). A*02\/B27<\/jats:styled-content>\/C*02\/DRB1<\/jats:styled-content>*01\/DQB1<\/jats:styled-content>*05<\/jats:italic> [P<\/jats:italic><0.0001; odds ratio (OR<\/jats:styled-content>)\u2009=\u200939.06; 95% confidence interval (CI<\/jats:styled-content>) (2.34\u2013651)] is the only haplotype that seems to confer susceptibility to AS<\/jats:styled-content>. Moreover, the haplotype A*02\/B27<\/jats:styled-content>\/C*01\/DRB1<\/jats:styled-content>*08\/DQB1<\/jats:styled-content>*04<\/jats:italic> seems to provide protection for disease functional and radiological repercussions. Our findings are compatible with the hypothesis that other genes within the HLA<\/jats:styled-content> region besides HLA\u2010B27<\/jats:styled-content> might play some role in AS<\/jats:styled-content> susceptibility and severity.<\/jats:p>","DOI":"10.1111\/tan.12238","type":"journal-article","created":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T10:21:28Z","timestamp":1385115688000},"page":"374-379","source":"Crossref","is-referenced-by-count":15,"title":["HLA<\/scp> alleles and HLA\u2010B27<\/scp> haplotypes associated with susceptibility and severity of ankylosing spondylitis in a Portuguese population"],"prefix":"10.1111","volume":"82","author":[{"given":"F. M.","family":"Pimentel\u2010Santos","sequence":"first","affiliation":[{"name":"CEDOC Faculdade de Ci\u00eancias M\u00e9dicas da Universidade Nova de Lisboa Lisbon Portugal"},{"name":"Centro Hospitalar Lisboa Ocidental (CHLO), Hospital de Egas Moniz, EPE Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Matos","sequence":"additional","affiliation":[{"name":"CEDOC Faculdade de Ci\u00eancias M\u00e9dicas da Universidade Nova de Lisboa Lisbon Portugal"},{"name":"IBB\/CGB Universidade de Tr\u00e1s\u2010os\u2010Montes e Alto Douro Vila Real Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Ligeiro","sequence":"additional","affiliation":[{"name":"Centro de Histocompatibilidade do Sul Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. F.","family":"Mour\u00e3o","sequence":"additional","affiliation":[{"name":"CEDOC Faculdade de Ci\u00eancias M\u00e9dicas da Universidade Nova de Lisboa Lisbon Portugal"},{"name":"Centro Hospitalar Lisboa Ocidental (CHLO), Hospital de Egas Moniz, EPE Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Lisboa Ocidental (CHLO), Hospital de Egas Moniz, EPE Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Costa","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Alto Minho (CHAM), Hospital Conde de Bertiandos, EPE Ponte de Lima Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Santos","sequence":"additional","affiliation":[{"name":"Instituto Portugu\u00eas de Reumatologia (IPR) Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Barcelos","sequence":"additional","affiliation":[{"name":"Hospital Infante D. Pedro, EPE Aveiro Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Centro Hospitalar de Vila Nova de Gaia\/Espinho, EPE Vila Nova de Gaia Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Cruz","sequence":"additional","affiliation":[{"name":"Centro Hospitalar das Caldas da Rainha Caldas da Rainha Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Sousa","sequence":"additional","affiliation":[{"name":"IMM, Faculdade de Medicina da Universidade de Lisboa Lisbon Portugal"},{"name":"Centro Hospitalar de Lisboa Norte, Hospital de santa Maria, EPE Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. A.","family":"Santos","sequence":"additional","affiliation":[{"name":"Hospital Militar Principal Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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