{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:38:38Z","timestamp":1790890718324,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T00:00:00Z","timestamp":1385078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tissue Antigens"],"published-print":{"date-parts":[[2013,12]]},"abstract":"Human leukocyte antigen (HLA<\/jats:styled-content>)\u2010B27<\/jats:styled-content> is closely associated with ankylosing spondylitis (AS<\/jats:styled-content>). However, the exact correlation between HLA\u2010B27<\/jats:styled-content> subtypes and AS<\/jats:styled-content> manifestations remains unknown. This study aimed to investigate the correlation between HLA\u2010B27<\/jats:styled-content> polymorphism and the clinical features of AS<\/jats:styled-content>. This study included 846 patients with AS<\/jats:styled-content> and 959 healthy controls. Direct sequencing was used to identify the HLA\u2010B27<\/jats:styled-content> genotype. Clinical parameters, including age, age of onset, family history, low back pain, peripheral arthritis, hip joint involvement, dactylitis, uveitis, and sex ratio, were compared among patients with various HLA\u2010B27<\/jats:styled-content> subtypes. In total, 741 AS<\/jats:styled-content> patients (87.6%) and 39 healthy controls (4%) were HLA\u2010B27<\/jats:styled-content>\u2010positive. The most prevalent subtypes were HLA<\/jats:styled-content>\u2010B*2704<\/jats:italic> (88%) and HLA<\/jats:styled-content>\u2010B*2705<\/jats:italic> (10.1%) in patients with AS<\/jats:styled-content>. Compared with HLA<\/jats:styled-content>\u2010B*2704<\/jats:italic>\u2010positive patients, HLA<\/jats:styled-content>\u2010B*2705<\/jats:italic>\u2010positive patients demonstrated a significant increase in the incidence of uveitis (16% vs<\/jats:italic> 6.13%, P<\/jats:italic>\u2009=\u20090.002) and dactylitis (9.3% vs<\/jats:italic> 3.8%, P<\/jats:italic>\u2009=\u20090.028) and they had an older age of onset (22.9\u2009\u00b1\u20098.0 vs<\/jats:italic> 20.7\u2009\u00b1\u20096.7\u2009years, P<\/jats:italic>\u2009=\u20090.028). Binary logistic regression analysis revealed that presence of uveitis was significantly associated with HLA<\/jats:styled-content>\u2010B*2705<\/jats:italic> (P<\/jats:italic>\u2009=\u20090.008; odds ratio, 2.63; 95% confidence interval, 1.283\u20135.393). There were no significant differences in family history, low back pain, peripheral arthritis, or hip joint involvement among HLA\u2010B27<\/jats:styled-content> subtypes. Specific HLA\u2010B27<\/jats:styled-content> subtypes were positively associated with particular clinical features of AS<\/jats:styled-content>. AS<\/jats:styled-content> patients with HLA<\/jats:styled-content>\u2010B*2705<\/jats:italic> demonstrated an older age of onset and had a higher risk of uveitis and dactylitis than did AS<\/jats:styled-content> patients with HLA<\/jats:styled-content>\u2010B*2704<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/tan.12254","type":"journal-article","created":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T10:21:28Z","timestamp":1385115688000},"page":"380-386","source":"Crossref","is-referenced-by-count":23,"title":["Higher risk of uveitis and dactylitis and older age of onset among ankylosing spondylitis patients with HLA<\/scp>\u2010B*2705<\/i> than patients with HLA<\/scp>\u2010B*2704<\/i> in the Chinese population"],"prefix":"10.1111","volume":"82","author":[{"given":"J.","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Rheumatology Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Rong","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou 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