{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T17:09:14Z","timestamp":1771952954066,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T00:00:00Z","timestamp":1387411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tissue Antigens"],"published-print":{"date-parts":[[2014,1]]},"abstract":"Abstract<\/jats:title>In order to study the impact of human leucocyte antigen (HLA<\/jats:styled-content>) polymorphism distribution in identifying a matched haematopoietic stem cells unrelated donor (UD), we performed a multi\u2010centric retrospective analysis with the aim of comparing the HLA<\/jats:styled-content>\u2010A, HLA<\/jats:styled-content>\u2010B, HLA<\/jats:styled-content>\u2010C, HLA\u2010DRB1<\/jats:styled-content> and HLA\u2010DQB1<\/jats:styled-content> phenotypes of 2126 patients (772 patients for whom a donor search failed to identify a matched UD, and 1354 patients who received a 10\/10 allele level matched UD). Our results showed that rare HLA<\/jats:styled-content>\u2010C is often responsible for difficulty in identifying a donor. This locus may add a degree of complexity to a supposed \u2018frequent\u2019 HLA<\/jats:styled-content>\u2010A HLA<\/jats:styled-content>\u2010B and HLA\u2010DRB1<\/jats:styled-content> phenotype, turning this phenotype into a less frequent one. For example, 32.5% of the phenotypes in the non\u2010transplanted patients could not be explained by any of the pairs of known HLA<\/jats:styled-content>\u2010A, HLA<\/jats:styled-content>\u2010B, HLA<\/jats:styled-content>\u2010C and HLA\u2010DRB1<\/jats:styled-content> haplotypes while this percentage dropped to less than 2% if combinations of only HLA<\/jats:styled-content>\u2010A, HLA<\/jats:styled-content>\u2010B and HLA\u2010DRB1<\/jats:styled-content> haplotypes were considered. Such situations can be anticipated by computing an index, based on HLA<\/jats:styled-content> haplotype frequency, the average registry sample size (ARS<\/jats:styled-content>). ARS<\/jats:styled-content> is defined as the inverse of the phenotype frequency computed using all corresponding pairs of haplotype frequencies. ARS<\/jats:styled-content> confirmed that the most significant difference between transplanted and non\u2010transplanted patients was correlated with the introduction of the locus HLA<\/jats:styled-content>\u2010C in the analysis (median: 8.3e\u2009+\u20094 vs<\/jats:italic> 3.1e\u2009+\u20096, P<\/jats:italic>\u2009<\u20090.0001). The higher the ARS<\/jats:styled-content> the lower the likelihood of finding a 10\/10 match UD reflecting the rareness of the patient's HLA<\/jats:styled-content>. The area under receiver operator characteristics (AUROC<\/jats:styled-content>) values of the ARS<\/jats:styled-content> computation for HLA<\/jats:styled-content>\u2010A, HLA<\/jats:styled-content>\u2010B and HLA\u2010DRB1<\/jats:styled-content> was 0.82 (0.80; 0.84) at a low\u2010resolution level (two digits). Overall, our study promotes the use of haplotype frequency\u2010based computations to develop computer\u2010assisted donor search.<\/jats:p>","DOI":"10.1111\/tan.12263","type":"journal-article","created":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T12:53:53Z","timestamp":1387457633000},"page":"17-26","source":"Crossref","is-referenced-by-count":8,"title":["HLA phenotypes of candidates for HSCT: comparing transplanted versus non\u2010transplanted candidates, resulting in the predictive estimation of the probability to find a 10\/10 HLA matched donor"],"prefix":"10.1111","volume":"83","author":[{"given":"P. A.","family":"Gourraud","sequence":"first","affiliation":[{"name":"Agence de la Biom\u00e9decine Registre France Greffe de Moelle Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. L.","family":"Bal\u00e8re","sequence":"additional","affiliation":[{"name":"Agence de la Biom\u00e9decine Registre France Greffe de Moelle Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Faucher","sequence":"additional","affiliation":[{"name":"Agence de la Biom\u00e9decine Registre France Greffe de Moelle Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Loiseau","sequence":"additional","affiliation":[{"name":"Laboratoire d'Histocompatibilit\u00e9 et d'immunologie Hopital Saint Louis Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Dormoy","sequence":"additional","affiliation":[{"name":"Laboratoire d'Immunog\u00e9n\u00e9tique Etablissement Fran\u00e7ais de Sang Bourgogne\u2010Franche\u2010Comt\u00e9 Besan\u00e7on France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Marry","sequence":"additional","affiliation":[{"name":"Agence de la Biom\u00e9decine Registre France Greffe de Moelle Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Garnier","sequence":"additional","affiliation":[{"name":"Agence de la Biom\u00e9decine Registre France Greffe de Moelle Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2009.09.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bfgp\/elp010"},{"key":"e_1_2_7_4_1","volume-title":"Genetics of Leukocyte Antigens: A Family Study of Segregation and Linkage. Copenhagen: Munksgaard","author":"Cepellini R","year":"1967"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2005.01.011"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.132"},{"key":"e_1_2_7_7_1","first-page":"3","article-title":"Bone Marrow Donors Worldwide: a successful exercise in international cooperation","volume":"14","author":"Oudshoorn M","year":"1994","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-097386"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2007.04.010"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040008"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201233"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2007.04.005"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2009.08.006"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.20024"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/303069"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199508270-00013"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1998.tb02277.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(96)00257-1"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2010.01520.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(98)00054-8"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-7364-2-1-39"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2009.01374.x"},{"key":"e_1_2_7_23_1","unstructured":"Saji H. 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Kyoto 2010.http:\/\/wwwhlaorjp\/hapro\/dlhtml."},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2009.01.015"}],"container-title":["Tissue Antigens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftan.12263","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.12263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T16:41:17Z","timestamp":1696005677000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tan.12263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,19]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/tan.12263"],"URL":"https:\/\/doi.org\/10.1111\/tan.12263","archive":["Portico"],"relation":{},"ISSN":["0001-2815","1399-0039"],"issn-type":[{"value":"0001-2815","type":"print"},{"value":"1399-0039","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,19]]}}}