{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:25:34Z","timestamp":1790760334409,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T00:00:00Z","timestamp":1389052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tissue Antigens"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatitis B virus (<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>) infection is one of the major causes of chronic liver inflammation. Tim\u20103 acts as a negative regulatory molecule and plays a critical role in immune tolerance. In the current study, we investigated Tim\u20103 expression on peripheral monocytes and <jats:styled-content style=\"fixed-case\">CD3<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">CD16<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CD56<\/jats:styled-content>+ natural killer like T (<jats:styled-content style=\"fixed-case\">NKT<\/jats:styled-content>\u2010like) cells in chronic hepatitis B (<jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content>) patients. Peripheral blood mononuclear cells (PBMCs) were isolated from 52 <jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content> patients and 60 healthy controls. Tim\u20103+<jats:styled-content style=\"fixed-case\">CD14<\/jats:styled-content>+ cells and Tim\u20103+<jats:styled-content style=\"fixed-case\">CD3<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">CD16<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CD56<\/jats:styled-content>+ cells were analyzed by flow cytometry. Results showed that expression of Tim\u20103 was significantly increased on both the monocytes and <jats:styled-content style=\"fixed-case\">NKT<\/jats:styled-content>\u2010like cells in <jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content> patients than in controls (<jats:italic>P<\/jats:italic>\u2009=\u20090.002 and <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, respectively). Tim\u20103 levels on monocytes and <jats:styled-content style=\"fixed-case\">NKT<\/jats:styled-content>\u2010like cells were further upregulated in patients with acute\u2010on\u2010chronic liver failure (<jats:styled-content style=\"fixed-case\">ACLF<\/jats:styled-content>). In addition, we assessed the correlation of Tim\u20103 expression with levels of alanine aminotransferase (<jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>) and tumor necrosis factor alpha (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1). Data revealed that Tim\u20103 expression on both monocytes and <jats:styled-content style=\"fixed-case\">NKT<\/jats:styled-content>\u2010like cells was positively correlated with level of <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u2009=\u20090.59, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, and <jats:italic>r<\/jats:italic>\u2009=\u20090.60, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, respectively), whereas Tim\u20103 expression on <jats:styled-content style=\"fixed-case\">NKT<\/jats:styled-content>\u2010like cells was negatively correlated with serum level of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.54, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) in <jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content> patients. Our results suggest that Tim\u20103 may play important roles in the pathogenesis of <jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/tan.12278","type":"journal-article","created":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T12:42:53Z","timestamp":1389098573000},"page":"76-81","source":"Crossref","is-referenced-by-count":30,"title":["Tim\u20103 expression on peripheral monocytes and <scp>CD3<\/scp>+<scp>CD16<\/scp>\/<scp>CD56<\/scp>+natural killer\u2010like T cells in patients with chronic hepatitis B"],"prefix":"10.1111","volume":"83","author":[{"given":"Y.\u2010H.","family":"Rong","sequence":"first","affiliation":[{"name":"Medical School of Chinese PLA Beijing China"},{"name":"Liver Failure Treatment and Research Center Beijing 302 Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.\u2010H.","family":"Wan","sequence":"additional","affiliation":[{"name":"Liver Failure Treatment and Research Center Beijing 302 Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases St. Joseph Hospital London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010L.","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Clinic Laboratory Medicine Beijing 302 Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Liver Failure Treatment and Research Center Beijing 302 Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Zang","sequence":"additional","affiliation":[{"name":"Liver Failure Treatment and Research Center Beijing 302 Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Liver diseases Center Weihai 404 Hospital Weihai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u2010L.","family":"Liu","sequence":"additional","affiliation":[{"name":"Liver Failure Treatment and Research Center Beijing 302 Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.\u2010M.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Liver Failure Treatment and Research Center Beijing 302 Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Xiao","sequence":"additional","affiliation":[{"name":"Liver Failure Treatment and Research Center Beijing 302 Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.\u2010J.","family":"Xin","sequence":"additional","affiliation":[{"name":"Liver Failure 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