{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:11:36Z","timestamp":1791321096555,"version":"4.3.1"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T00:00:00Z","timestamp":1389052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tissue Antigens"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human papillomavirus (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>) infection is involved in cervical lesion development. It interferes with host immune response and modifies the expression of human leukocyte antigen\u2010G (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010G), a nonclassical <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010I antigen with immune\u2010inhibitory functions. We analyzed the frequencies of two <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010G 3\u2032 untranslated region polymorphisms (14\u2009bp <jats:italic>ins\/del<\/jats:italic>, +3142<jats:italic>C&gt;G<\/jats:italic>), involved in HLA\u2010G modulation, in 33 condyloma acuminatum, 14 low grade squamous intraepithelial lesion and 100 invasive cervical cancer (ICC) HPV infected patients. We showed the involvement of HLA\u2010G polymorphisms in HPV infection and lesion development, and suggested that 14\u2009bp <jats:italic>del<\/jats:italic> allele promotes high\u2010risk HPV infection, with <jats:italic>del\/C<\/jats:italic> haplotype associated with ICC development. On the basis of these evidences, HLA\u2010G polymorphisms could represent a risk factor in HPV positive subjects.<\/jats:p>","DOI":"10.1111\/tan.12281","type":"journal-article","created":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T12:43:03Z","timestamp":1389098583000},"page":"113-118","source":"Crossref","is-referenced-by-count":37,"title":["Implication of <scp>HLA<\/scp>\u2010G 3\u2032 untranslated region polymorphisms in human papillomavirus infection"],"prefix":"10.1111","volume":"83","author":[{"given":"D.","family":"Bortolotti","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Section of Microbiology and Medical Genetics University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Gentili","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Section of Microbiology and Medical Genetics University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Rotola","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Section of Microbiology and Medical Genetics University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Di Luca","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Section of Microbiology and Medical Genetics University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Section of Microbiology and Medical Genetics University of Ferrara Ferrara 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