{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:23:34Z","timestamp":1787016214981,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T00:00:00Z","timestamp":1392854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tissue Antigens"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We describe 2127 new human leukocyte antigen (\n                    <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\n                    ) class I alleles found in registered stem cell donors. These alleles represent 28.9% of the currently known class I alleles. Comparing new allele sequences to homologous sequences, we found 68.1% nonsynonymous nucleotide substitutions, 28.9% silent mutations and 3.0% nonsense mutations. Many substitutions occurred at positions that have not been known to be polymorphic before. A large number of\n                    <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\n                    alleles and nucleotide variations underline the extreme diversity of the\n                    <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\n                    system. Strikingly, 156 new alleles were found not only multiple times, but also in carriers of various parentage, suggesting that some new alleles are not necessarily rare. Moreover, new alleles were found especially often in minority donors. This emphasizes the benefits of specifically recruiting such groups of individuals.\n                  <\/jats:p>","DOI":"10.1111\/tan.12304","type":"journal-article","created":{"date-parts":[[2014,2,21]],"date-time":"2014-02-21T20:47:26Z","timestamp":1393015646000},"page":"184-189","source":"Crossref","is-referenced-by-count":40,"title":["Identification of 2127 new\n                    <scp>HLA<\/scp>\n                    class I alleles in potential stem cell donors from Germany, the United States and Poland"],"prefix":"10.1111","volume":"83","author":[{"given":"C. J.","family":"Hern\u00e1ndez\u2010Frederick","sequence":"first","affiliation":[{"name":"DKMS German Bone Marrow Donor Center T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. S.","family":"Giani","sequence":"additional","affiliation":[{"name":"DKMS German Bone Marrow Donor Center T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Cereb","sequence":"additional","affiliation":[{"name":"HistoGenetics, Inc. Ossining New York, NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sauter","sequence":"additional","affiliation":[{"name":"DKMS German Bone Marrow Donor Center T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Silva\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"DKMS German Bone Marrow Donor Center T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Pingel","sequence":"additional","affiliation":[{"name":"DKMS German Bone Marrow Donor Center T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. H.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"DKMS German Bone Marrow Donor Center T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Ehninger","sequence":"additional","affiliation":[{"name":"Internal Medicine I University Hospital Carl Gustav Carus Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Y.","family":"Yang","sequence":"additional","affiliation":[{"name":"HistoGenetics, Inc. Ossining New York, NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,20]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2010.01466.x"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq998"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2009.01285.x"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12132"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1995.tb02408.x"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1997.tb02839.x"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31829bfe2f"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks949"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1995.tb00674.x"},{"key":"e_1_2_3_11_1","unstructured":"WMDA reference website. List of letter codes for encoding of allelic ambiguities.http:\/\/bioinformatics.nmdp.org\/HLA\/Allele_Codes\/Allele_Codes.aspx."},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2007.01.014"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2009.55"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2012.10.029"}],"container-title":["Tissue Antigens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftan.12304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.12304","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tan.12304","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.12304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T06:26:19Z","timestamp":1696141579000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tan.12304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,20]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/tan.12304"],"URL":"https:\/\/doi.org\/10.1111\/tan.12304","archive":["Portico"],"relation":{},"ISSN":["0001-2815","1399-0039"],"issn-type":[{"value":"0001-2815","type":"print"},{"value":"1399-0039","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,20]]}}}