{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T15:37:29Z","timestamp":1765294649450},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,3,26]],"date-time":"2014-03-26T00:00:00Z","timestamp":1395792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tissue Antigens"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study investigated the genetic polymorphisms of <jats:styled-content style=\"fixed-case\">HLA\u2010B27<\/jats:styled-content>, together with polymorphisms on endoplasmic reticulum aminopeptidase 1 (<jats:styled-content style=\"fixed-case\">ERAP1<\/jats:styled-content>), and susceptibility for ankylosing spondylitis (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>) in the Beijing Han population. A case\u2010control study was carried out for 602 <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> patient samples and 619 matched controls of Han Chinese. <jats:styled-content style=\"fixed-case\">HLA\u2010B27<\/jats:styled-content> genotyping was performed by polymerase chain reaction\u2010sequence specific primers (<jats:styled-content style=\"fixed-case\">PCR\u2010SSP<\/jats:styled-content>), and four <jats:styled-content style=\"fixed-case\">ERAP1 SNPs<\/jats:styled-content> (rs27037, rs27980, rs27582, and rs27434) were selected and genotyped on the Sequenom <jats:styled-content style=\"fixed-case\">iPlex<\/jats:styled-content> platform (Sequenom, San Diego, CA). Association analysis was performed using the likelihood ratio <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> test. This study identified four <jats:styled-content style=\"fixed-case\">HLA\u2010B27<\/jats:styled-content> alleles in Beijing Han <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> patients, <jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>*27:02<\/jats:italic>, <jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>*27:04<\/jats:italic>, <jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>*27:05<\/jats:italic>, and <jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>*27:07<\/jats:italic>, of which <jats:italic><jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>*27:05<\/jats:italic> was the most significant geographical different subtype among <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> patients in Chinese. Our results confirmed that <jats:styled-content style=\"fixed-case\">HLA\u2010B27<\/jats:styled-content> was strongly associated with <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u2009=\u20091.9\u2009\u00d7\u200910<jats:sup>\u2212150<\/jats:sup>), and the most strongly associated alleles were <jats:italic>B*27:04<\/jats:italic>, <jats:italic>B*27:05<\/jats:italic>, and <jats:italic>B*27:02<\/jats:italic>. Our study also confirmed a weak association between <jats:styled-content style=\"fixed-case\">ERAP1<\/jats:styled-content> (rs27434) and <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>. We also observed that for <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*27:02<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*27:04<\/jats:italic> positive <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> patients, rs27434 and rs27582 were associated with <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>. In contrast, for <jats:styled-content style=\"fixed-case\">HLA\u2010B27<\/jats:styled-content>\u2010negative and <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*27:05<\/jats:italic>\u2010positive <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> patients, this association was not observed. This is the first study to show that both <jats:styled-content style=\"fixed-case\">B27<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ERAP1<\/jats:styled-content> are <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> genetic susceptibility genes in Beijing Han. Interactions between <jats:styled-content style=\"fixed-case\">ERAP1<\/jats:styled-content> and <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*27:02<\/jats:italic> and <jats:italic>B*27:04<\/jats:italic> may play an important role in the <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> pathogenesis.<\/jats:p>","DOI":"10.1111\/tan.12334","type":"journal-article","created":{"date-parts":[[2014,3,26]],"date-time":"2014-03-26T05:22:45Z","timestamp":1395811365000},"page":"324-329","source":"Crossref","is-referenced-by-count":23,"title":["Association of <scp>HLA\u2010B27<\/scp> and <scp>ERAP1<\/scp> with ankylosing spondylitis susceptibility in Beijing Han Chinese"],"prefix":"10.1111","volume":"83","author":[{"given":"Z.","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Immunology Beijing 307 Hospital Affiliated to Academy of Medical Sciences Beijing China"},{"name":"Institute of Beijing 307 Hospital Anhui Medical College Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Immunology Beijing 307 Hospital Affiliated to Academy of Medical Sciences Beijing China"},{"name":"Institute of Beijing 307 Hospital Anhui Medical College Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Immunology Beijing 307 Hospital Affiliated to Academy of Medical Sciences Beijing China"},{"name":"Institute of Beijing 307 Hospital Anhui Medical College Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Immunology Beijing 307 Hospital Affiliated to Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Immunology Beijing 307 Hospital Affiliated to Academy of Medical Sciences Beijing China"},{"name":"Department of Immunology Union University of Hebei Shi Jia Zhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Immunology Beijing 307 Hospital Affiliated to Academy of Medical Sciences Beijing China"},{"name":"Department of Immunology Union University of Hebei Shi Jia Zhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Immunology Beijing 307 Hospital Affiliated to Academy of Medical Sciences Beijing China"},{"name":"Department of Immunology Union University of Hebei Shi Jia Zhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Immunology Beijing 307 Hospital Affiliated to Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Immunology Beijing 307 Hospital Affiliated to Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Immunology Beijing 307 Hospital Affiliated to Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Immunology Beijing 307 Hospital Affiliated to Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Immunology Beijing 307 Hospital Affiliated to Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.\u2010Y.","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Immunology Beijing 307 Hospital Affiliated to Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,26]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"463","article-title":"Heritability estimates on ankylosing spondylitis","volume":"24","author":"Pedersen O","year":"2006","journal-title":"Clin Exp 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