{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T22:42:27Z","timestamp":1775688147153,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T00:00:00Z","timestamp":1398211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Chinese High Tech Research & Development(863) Program","award":["2012AA020204"],"award-info":[{"award-number":["2012AA020204"]}]},{"name":"the Program for Innovative Research Team of Zhejiang Province of China","award":["2009R50038"],"award-info":[{"award-number":["2009R50038"]}]},{"name":"ZhejiangProvincialNaturalScienceFoundation","award":["LY13H160004"],"award-info":[{"award-number":["LY13H160004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tissue Antigens"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although the involvement of insulin\u2010like signaling in cancer has been well documented in various types of cancers, the association between the genetic variants in the insulin\u2010like signaling and the development of hepatitis B virus (<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>)\u2010related hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>) remains unclear. In this study, a total of 498 individuals including 173 <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> related cirrhosis patients, 171 <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\u2010related <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> patients, and 154 healthy controls were enrolled. Sixteen single nucleotide polymorphisms (SNPs) in <jats:styled-content style=\"fixed-case\">IGF1<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">IGF2<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">IGF1R<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IGF2R<\/jats:styled-content> have been genotyped by employing <jats:styled-content style=\"fixed-case\">SNaPshot<\/jats:styled-content> assays. We found A\/A genotype at rs3743251 of <jats:styled-content style=\"fixed-case\">IGF1R<\/jats:styled-content> was negatively associated with <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> related <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>)\u2009=\u20090.38, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>)\u2009=\u20090.20\u20130.72, <jats:italic>P<\/jats:italic>\u2009=\u20090.037]; A\/G genotype decreased the risk of portal vein thrombosis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2009=\u20090.38, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u2009=\u20090.18\u20130.82, <jats:italic>P<\/jats:italic>\u2009=\u20090.01). These results indicate that rs3743251 polymorphism in <jats:styled-content style=\"fixed-case\">IGF1R<\/jats:styled-content> is associated with the susceptibility of <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\u2010related <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/tan.12360","type":"journal-article","created":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T13:10:45Z","timestamp":1398258645000},"page":"264-270","source":"Crossref","is-referenced-by-count":2,"title":["Association of <scp>IGF1R<\/scp> polymorphisms with the development of <scp>HBV<\/scp>\u2010related hepatocellular carcinoma"],"prefix":"10.1111","volume":"84","author":[{"given":"H.\u2010Y.","family":"Xie","sequence":"first","affiliation":[{"name":"Division of Hepatobiliary Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Key Laboratory of Combined Multi\u2010organ Transplantation, Ministry of Public Health. Key Laboratory of Organ Transplantation, Collaborative innovation center for Diagnosis treatment of infectious diseases Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.\u2010Y.","family":"Xing","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Key Laboratory of Combined Multi\u2010organ Transplantation, Ministry of Public Health. Key Laboratory of Organ Transplantation, Collaborative innovation center for Diagnosis treatment of infectious diseases Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.\u2010J.","family":"Wei","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Key Laboratory of Combined Multi\u2010organ Transplantation, Ministry of Public Health. Key Laboratory of Organ Transplantation, Collaborative innovation center for Diagnosis treatment of infectious diseases Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Xu","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Key Laboratory of Combined Multi\u2010organ Transplantation, Ministry of Public Health. Key Laboratory of Organ Transplantation, Collaborative innovation center for Diagnosis treatment of infectious diseases Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Key Laboratory of Combined Multi\u2010organ Transplantation, Ministry of Public Health. Key Laboratory of Organ Transplantation, Collaborative innovation center for Diagnosis treatment of infectious diseases Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.\u2010M.","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Key Laboratory of Combined Multi\u2010organ Transplantation, Ministry of Public Health. Key Laboratory of Organ Transplantation, Collaborative innovation center for Diagnosis treatment of infectious diseases Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.\u2010Q.","family":"Cao","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Key Laboratory of Combined Multi\u2010organ Transplantation, Ministry of Public Health. Key Laboratory of Organ Transplantation, Collaborative innovation center for Diagnosis treatment of infectious diseases Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Key Laboratory of Combined Multi\u2010organ Transplantation, Ministry of Public Health. Key Laboratory of Organ Transplantation, Collaborative innovation center for Diagnosis treatment of infectious diseases Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.\u2010J.","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Key Laboratory of Combined Multi\u2010organ Transplantation, Ministry of Public Health. Key Laboratory of Organ Transplantation, Collaborative innovation center for Diagnosis treatment of infectious diseases Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010Y.","family":"Yin","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Key Laboratory of Combined Multi\u2010organ Transplantation, Ministry of Public Health. Key Laboratory of Organ Transplantation, Collaborative innovation center for Diagnosis treatment of infectious diseases Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.\u2010M.","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Key Laboratory of Combined Multi\u2010organ Transplantation, Ministry of Public Health. 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