{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:24:28Z","timestamp":1759047868502},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T00:00:00Z","timestamp":1410480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tissue Antigens"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have characterized 372 novel human leukocyte antigen (HLA) class II alleles identified in newly registered stem cell donors, this includes 281 HLA\u2010DRB1 alleles, 89 HLA\u2010DQB1 alleles and 2 HLA\u2010DPB1 alleles. Most novel alleles were single nucleotide variants when compared to their respective most homologous alleles. In 66.4% of all novel alleles non\u2010synonymous nucleotide variations were identified, in 30.4% synonymous substitutions and in 3.2% nonsense mutations. Ninty\u2010three (25.0%) novel alleles were found in several individuals; most often these were novel HLA\u2010DRB1 alleles. Lastly, we underline the importance of recruiting ethnic minority donors in countries such as Germany and the United States, as novel alleles were frequently found among these groups.<\/jats:p>","DOI":"10.1111\/tan.12432","type":"journal-article","created":{"date-parts":[[2014,9,13]],"date-time":"2014-09-13T02:27:14Z","timestamp":1410575234000},"page":"497-502","source":"Crossref","is-referenced-by-count":8,"title":["Three hundred and seventy\u2010two novel <scp>HLA<\/scp> class <scp>II<\/scp> alleles identified in potential hematopoietic stem cell donors from Germany, the United States, and Poland"],"prefix":"10.1111","volume":"84","author":[{"given":"C. J.","family":"Hern\u00e1ndez\u2010Frederick","sequence":"first","affiliation":[{"name":"DKMS German Bone Marrow Donor Center  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Cereb","sequence":"additional","affiliation":[{"name":"HistoGenetics, Inc.  Ossining NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. S.","family":"Giani","sequence":"additional","affiliation":[{"name":"DKMS German Bone Marrow Donor Center  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Ruppel","sequence":"additional","affiliation":[{"name":"Delete Blood Cancer DKMS US  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Maraszek","sequence":"additional","affiliation":[{"name":"DKMS Polska  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Pingel","sequence":"additional","affiliation":[{"name":"DKMS German Bone Marrow Donor Center  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Sauter","sequence":"additional","affiliation":[{"name":"DKMS German Bone Marrow Donor Center  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. H.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"DKMS German Bone Marrow Donor Center  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Y.","family":"Yang","sequence":"additional","affiliation":[{"name":"HistoGenetics, Inc.  Ossining NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,12]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020268"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2011.03.010"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2012.07.240"},{"key":"e_1_2_4_5_1","first-page":"270","article-title":"Simulation shows that registered stem cell donors with full donor\u2010patient HLA\u2010match can remain unidentified","volume":"81","author":"Schmidt AH","year":"2013","journal-title":"Tissue Antigens"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086605"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2010.01466.x"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq998"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12304"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2009.01321.x"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12182"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks949"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2009.55"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2012.10.029"}],"container-title":["Tissue Antigens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftan.12432","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.12432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T09:57:32Z","timestamp":1695981452000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tan.12432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,12]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1111\/tan.12432"],"URL":"https:\/\/doi.org\/10.1111\/tan.12432","archive":["Portico"],"relation":{},"ISSN":["0001-2815","1399-0039"],"issn-type":[{"value":"0001-2815","type":"print"},{"value":"1399-0039","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,12]]}}}