{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:46:13Z","timestamp":1791477973743,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T00:00:00Z","timestamp":1416528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"LIGH-FUNPAR"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tissue Antigens"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>HLA\u2010F is a non\u2010classical major histocompatibility complex (MHC) gene. It codes class Ib MHC molecules with restricted distribution and less nucleotide variations than MHC class Ia genes. Of the 22 alleles registered on the IMGT database only four alleles encode for proteins that differ in their primary structure. To estimate genotype and allele frequencies, this study targeted on known protein coding regions of the HLA\u2010F gene. Genotyping was performed by Sequence Base Typing (SBT). The sample was composed by 199\u2010unrelated bone marrow donors from the Brazilian Bone Marrow Donor Registry (REDOME), Euro\u2010Brazilians, from Southern Brazil. About 1673\u2009bp were analyzed. The most frequent allele was <jats:italic>HLA\u2010F*01:01<\/jats:italic> (87.19%), followed by <jats:italic>HLA\u2010F*01:03<\/jats:italic> (12.31%), <jats:italic>HLA\u2010F*01:02<\/jats:italic> (0.25%) and <jats:italic>HLA\u2010F*01:04<\/jats:italic> (0.25%). Significant linkage disequilibrium (LD) was verified between HLA\u2010F and HLA classes I and II alleles. This is the first study regarding HLA\u2010F polymorphisms in a Euro\u2010Brazilian population contributing to the Southern Brazilian genetic characterization.<\/jats:p>","DOI":"10.1111\/tan.12444","type":"journal-article","created":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T11:24:09Z","timestamp":1416569049000},"page":"554-559","source":"Crossref","is-referenced-by-count":13,"title":["<scp>HLA<\/scp>\u2010F polymorphisms in a Euro\u2010Brazilian population from Southern Brazil"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7336-1881","authenticated-orcid":false,"given":"L. F. S.","family":"Manvailer","sequence":"first","affiliation":[{"name":"Laboratory of Immunogenetics and Histocompatibility, Genetics Department Universidade Federal do Paran\u00e1  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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