{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T11:13:10Z","timestamp":1723201990079},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,11,23]],"date-time":"2014-11-23T00:00:00Z","timestamp":1416700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tissue Antigens"],"published-print":{"date-parts":[[2015,1]]},"abstract":"Abstract<\/jats:title>Aortic dissection (AD<\/jats:styled-content>) is a disease characterized by a tear in the aortic intimal layer and separation of the arterial wall. Some risk factors, such as hypertension and Marfan syndrome, are well known in AD<\/jats:styled-content>, but the role of genetic factor is largely unknown. In this study, we investigated the relation between two single nucleotide polymorphisms (SNPs<\/jats:styled-content>) identified by genome\u2010wide association study and AD<\/jats:styled-content>. Approximately 177 patients diagnosed with AD<\/jats:styled-content> through clinical evaluation and imaging techniques and 183 age\u2010 and sex\u2010matched control subjects who were suffering from chest pain but without AD<\/jats:styled-content> were included in the study. Genotyping of rs10263935 and rs6045676 was performed in both patients and control subjects using the TaqMan<\/jats:styled-content>\u00ae<\/jats:sup> method [Life Technologies (AB & Invitrogen), Carlsbad, CA]. The frequency of the AA<\/jats:styled-content> and AG<\/jats:styled-content> genotype in rs10263935 was significantly higher in the AD<\/jats:styled-content> patients (0.085 and 0.435, respectively) than in the control subjects (0.033 and 0.355, respectively). The rs10263935 A allele frequency in the AD<\/jats:styled-content> patients was higher than that in the control subjects [0.302 vs<\/jats:italic> 0.210, odds ratio (OR<\/jats:styled-content>) = 1.62, 95% confidence interval (CI<\/jats:styled-content>): 1.26\u20132.28, P<\/jats:italic> = 0.005]. Similarly, the frequency of the GG<\/jats:styled-content> genotype in rs6045676 was significantly higher in the AD<\/jats:styled-content> patients than in the control subjects (0.107 vs<\/jats:italic> 0.038, P<\/jats:italic> = 0.015). The rs6045676 G allele frequency in the AD<\/jats:styled-content> patients was higher than that in the control subjects (0.282 vs<\/jats:italic> 0.191, OR<\/jats:styled-content> = 1.67, 95% CI<\/jats:styled-content>: 1.18\u20132.50, P<\/jats:italic> = 0.004). After adjustment of the confounding factors, such as smoking, sex, and age, the differences remain significant in several models (rs10263935: GG<\/jats:styled-content> vs<\/jats:italic> AA<\/jats:styled-content>: OR<\/jats:styled-content> = 3.13, 95% CI<\/jats:styled-content>: 1.15\u20138.33, P<\/jats:italic> = 0.025; GG<\/jats:styled-content> vs<\/jats:italic> AG<\/jats:styled-content>: OR<\/jats:styled-content> = 1.57, 95% CI<\/jats:styled-content>: 1.01\u20132.44, P<\/jats:italic> = 0.045; rs6045676: GG<\/jats:styled-content> vs<\/jats:italic> CC<\/jats:styled-content>: OR<\/jats:styled-content> = 3.30, 95% CI<\/jats:styled-content>: 1.32\u20138.25, P<\/jats:italic> = 0.011). rs10263935 on chromosome 7 and rs6045676 on chromosome 20 are associated with AD<\/jats:styled-content>. Further studies are warranted to elucidate the functional role of these two variants.<\/jats:p>","DOI":"10.1111\/tan.12448","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T03:29:06Z","timestamp":1416799746000},"page":"10-14","source":"Crossref","is-referenced-by-count":1,"title":["rs10263935 and rs6045676 identified by genome\u2010wide association study were associated with aortic dissection in a Chinese population"],"prefix":"10.1111","volume":"85","author":[{"given":"Chuan","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Xinqiao Hospital Third Military Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Xinqiao Hospital Third Military Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying\u2010Bin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Xinqiao Hospital Third Military Medical University Chongqing 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