{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:18:20Z","timestamp":1791303500417,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T00:00:00Z","timestamp":1421107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Collaborative Transplant Study (CTS)"},{"name":"The Scientific and Technological Research Council of Turkey (TUBITAK)"},{"name":"Deutsche Forschungsgemeinschaft (DFG)","award":["GZ:446TUR112\/8\/05"],"award-info":[{"award-number":["GZ:446TUR112\/8\/05"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tissue Antigens"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Complement\u2010mediated humoral rejection has become the main focus of research in organ transplantation. The aim of this study was to investigate the possible association of the complement <jats:styled-content style=\"fixed-case\">C5aR<\/jats:styled-content> gene 450 C\/T polymorphism in antibody\u2010mediated renal allograft rejection. This polymorphism was investigated in 290 first deceased donor kidney graft recipients with well functioning grafts and no rejection treatment during the first transplant year (<jats:styled-content style=\"fixed-case\">WFG<\/jats:styled-content>), 265 recipients with graft failure within the first transplant year (F), and 187 healthy controls. Frequency of the 450 <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> genotype was lower in the total population of 555 kidney recipients (4.7%) than in 187 healthy controls (8.6%), but the difference was not statistically significant (<jats:italic>P<\/jats:italic>\u2009=\u20090.065). A significantly higher frequency of <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> genotype was found in F patients (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>: 6.8%) when compared to <jats:styled-content style=\"fixed-case\">WFG<\/jats:styled-content> patients (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>: 2.8%, <jats:italic>P<\/jats:italic>\u2009=\u20090.027). The <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> genotype was also significantly lower in <jats:styled-content style=\"fixed-case\">WFG<\/jats:styled-content> patients than in healthy controls (<jats:italic>P<\/jats:italic>\u2009=\u20090.009). Low frequency of the <jats:styled-content style=\"fixed-case\">C5aR<\/jats:styled-content> 450 <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> genotype, which apparently is a feature of certain kidney diseases, appears to be associated with good graft outcome in kidney transplantation and might be helpful for identifying recipients who are at low risk for graft rejection.<\/jats:p>","DOI":"10.1111\/tan.12495","type":"journal-article","created":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T06:40:07Z","timestamp":1421131207000},"page":"104-107","source":"Crossref","is-referenced-by-count":7,"title":["Complement C5a receptor gene 450 C\/T polymorphism in renal transplant recipients: association of the <scp>CT<\/scp> genotype with graft outcome"],"prefix":"10.1111","volume":"85","author":[{"given":"R.","family":"G\u00fcnesacar","sequence":"first","affiliation":[{"name":"Department of Medical Biology and Genetics, Faculty of Medicine University of Kahramanmaras S\u00fctc\u00fc Imam  Kahramanmaras Turkey"},{"name":"Department of Transplantation Immunology, Institute of Immunology University of Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Opelz","sequence":"additional","affiliation":[{"name":"Department of Transplantation Immunology, Institute of Immunology University of Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Erken","sequence":"additional","affiliation":[{"name":"Department of Immunology\u2010Rheumatology, Faculty of Medicine University of Cukurova  Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"D\u00f6hler","sequence":"additional","affiliation":[{"name":"Department of Transplantation Immunology, Institute of Immunology University of Heidelberg  Heidelberg 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