{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T18:00:37Z","timestamp":1783792837032,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T00:00:00Z","timestamp":1422403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Instituto Maimonides para investigacion Biomedica de Cordoba (IMIBIC)"},{"name":"Rheumatology Department, Reina Sophia Hospital, Cordoba"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tissue Antigens"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Abstract<\/jats:title>Ankylosing spondylitis (AS<\/jats:styled-content>) is very often associated with human leukocyte antigen (HLA<\/jats:styled-content>), particularly HLA<\/jats:styled-content>\u2010B*27<\/jats:italic>. However, the strength of this association and clinical features may vary in different ethnic groups. Our study aims to assess the distribution of HLA<\/jats:styled-content>\u2010A, \u2010B, \u2010Cw and DRB1<\/jats:styled-content> alleles in Moroccan patients with AS<\/jats:styled-content> and to compare the clinical features of AS<\/jats:styled-content> and the frequencies of HLA\u2010B27<\/jats:styled-content> in patients from Morocco with other series. Seventy\u2010five patients diagnosed with AS<\/jats:styled-content> and assessed for clinical manifestations were selected and compared to 100 healthy controls. HLA<\/jats:styled-content> class I and II<\/jats:styled-content> antigens were typed by polymerase chain reaction sequence\u2010specific oligonucleotide. HLA\u2010B27<\/jats:styled-content> subtypes were studied by polymerase chain reaction amplification with sequence\u2010specific primers. HLA<\/jats:styled-content>\u2010B27 was found in 64% of patients. It was positively associated with younger age at disease onset, family history, and uveitis while it had a negative association with late onset. Six B*27<\/jats:italic> subtypes were identified in the AS<\/jats:styled-content> group. HLA<\/jats:styled-content>\u2010B*2705<\/jats:italic> and B*2702<\/jats:italic> were the most common observed subtypes. Among other HLA<\/jats:styled-content> genes, a significant increase in the prevalence of HLA<\/jats:styled-content>\u2010Cw*02<\/jats:italic> and HLA\u2010DRB<\/jats:styled-content>*15<\/jats:italic> was found in AS<\/jats:styled-content> patients. HLA\u2010B27<\/jats:styled-content> is involved in the predisposition of AS<\/jats:styled-content> in the Moroccan population. HLA<\/jats:styled-content>\u2010B*2705<\/jats:italic> and B*2702<\/jats:italic> were the predominant subtypes supporting previous reports in Caucasian spondyloarthropathies. Other HLA<\/jats:styled-content> genes, HLA<\/jats:styled-content>\u2010Cw*02<\/jats:italic> and HLA\u2010DRB1<\/jats:styled-content>*15<\/jats:italic>, seem to confer predisposing effect to the disease. However, the lower frequency of HLA<\/jats:styled-content>\u2010B27<\/jats:styled-content><\/jats:italic> compared to the literature in our study suggests the existence of different genetic and\/or environmental factors in Morocco.<\/jats:p>","DOI":"10.1111\/tan.12515","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T07:59:03Z","timestamp":1422431943000},"page":"108-116","source":"Crossref","is-referenced-by-count":14,"title":["Polymorphisms of HLA\u2010A, \u2010B, \u2010Cw and DRB1 antigens in Moroccan patients with ankylosing spondylitis and a comparison of clinical features with frequencies of HLA\u2010B*27<\/i>"],"prefix":"10.1111","volume":"85","author":[{"given":"I.","family":"El Mouraghi","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Sciences University Abdelmalek Essaidi T\u00e9touan Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ouarour","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Sciences University Abdelmalek Essaidi T\u00e9touan Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Ghozlani","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Military Hospital Mohammed V Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Collantes","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Reina Sophia Hospital Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Solana","sequence":"additional","affiliation":[{"name":"Immunology Unit, Instituto Maimonides para investigacion Biomedica de Cordoba (IMIBIC) Reina Sophia Hospital Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"El Maghraoui","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Military Hospital Mohammed V Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0755-4982(04)98954-3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2011.06.006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem084"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-007-0622-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-002-0237-4"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91360-3"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197304052881403"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2012.01944.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2013.852856"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-010-0126-x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-013-0347-x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364362"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/860651"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204484"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-203169"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.patbio.2012.01.001"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-1079-0"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.12691\/ajmbr-1-1-5"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1997.tb02724.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.56.1.68"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200007000-00008"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(94)90005-1"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2005.00379.x"},{"key":"e_1_2_8_26_1","first-page":"7","article-title":"Variation in HLA\u2010B27 gene subtypes and susceptibility of ankylosing spondylitis in the Croatian population","volume":"48","author":"Grubic Z","year":"2001","journal-title":"Reumatizam"},{"key":"e_1_2_8_27_1","first-page":"465","article-title":"Prevalence of HLA\u2010B27 and subtypes of HLA\u2010B27 associated with ankylosing spondylitis in Galicia, Spain","volume":"22","author":"Fernandez\u2010Sueiro JL","year":"2004","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_28_1","first-page":"41","article-title":"Race\u2010related differences in HLA association with ankylosing spondylitis and Reiter's disease in American blacks and whites","volume":"70","author":"Khan MA","year":"1978","journal-title":"J Natl Med Assoc"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-1018-0"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2001.580105.x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200003)43:3<485::AID-ANR2>3.0.CO;2-0"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2001.580407.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(03)00085-5"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-008-9183-6"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1155\/1993\/819041"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-0840-8"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(01)00370-6"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2006.12.003"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.041103"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12238"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-007-0727-6"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-011-1819-x"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-0873-z"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12254"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2370.2002.00289.x"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2010.01498.x"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2006.11.003"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-014-2574-6"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-2099-0"}],"container-title":["Tissue Antigens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftan.12515","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.12515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T21:31:15Z","timestamp":1696195875000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tan.12515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,28]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/tan.12515"],"URL":"https:\/\/doi.org\/10.1111\/tan.12515","archive":["Portico"],"relation":{},"ISSN":["0001-2815","1399-0039"],"issn-type":[{"value":"0001-2815","type":"print"},{"value":"1399-0039","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,28]]}}}