{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:58:12Z","timestamp":1790949492331,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T00:00:00Z","timestamp":1423180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81160017"],"award-info":[{"award-number":["81160017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tissue Antigens"],"published-print":{"date-parts":[[2015,3]]},"abstract":"Abstract<\/jats:title>Serum amyloid A (SAA<\/jats:styled-content>) protein is not only an inflammatory factor but also an apolipoprotein that can replace apolipoprotein A1<\/jats:styled-content> (apoA1<\/jats:styled-content>) as the major apolipoprotein of high\u2010density lipoprotein cholesterol (HDL<\/jats:styled-content>\u2010C). However, the relationship between genetic polymorphisms of SAA<\/jats:styled-content> and coronary artery disease (CAD<\/jats:styled-content>) remains unclear. A total of four single nucleotide polymorphisms (rs12218, rs4638289, rs7131332, and rs11603089) of the SAA<\/jats:styled-content> gene were genotyped using the polymerase chain reaction\u2010restriction fragment length polymorphism (PCR\u2010RFLP<\/jats:styled-content>) method in two independent case\u2013control studies, one of the Han population (1416 CAD<\/jats:styled-content> patients and 1373 control subjects) and the other of the Uygur population (588 CAD<\/jats:styled-content> patients and 529 control subjects). We found that the rs12218 CC<\/jats:styled-content> genotype was more frequent among the CAD<\/jats:styled-content> patients than among the controls in both the Han (8.3% vs. 4.8%, P<\/jats:italic>\u2009<\u20090.001) and Uygur populations (15.5% vs. 11.3%, P<\/jats:italic>\u2009<\u20090.05). After adjustments for confounding factors, such as sex, age, smoking, drinking, hypertension, diabetes, and serum levels of triglycerides, total cholesterol, HDL, and plasma SAA<\/jats:styled-content>, the differences remained significant in the Han (CC<\/jats:styled-content> vs. CT<\/jats:styled-content>+TT<\/jats:styled-content>, P<\/jats:italic>\u2009<\u20090.001, OR<\/jats:styled-content>\u2009=\u20093.863, 95% CI<\/jats:styled-content>: 1.755\u201312.477) and Uygur groups (CC<\/jats:styled-content> vs. CT<\/jats:styled-content>+TT<\/jats:styled-content>, P<\/jats:italic>\u2009=\u20090.031, OR<\/jats:styled-content>\u2009=\u20093.022, 95% CI<\/jats:styled-content>: 1.033\u20138.840). Genetic polymorphisms in SAA1<\/jats:styled-content> are associated with CAD<\/jats:styled-content> in the Han and Uygur populations in western China.<\/jats:p>","DOI":"10.1111\/tan.12516","type":"journal-article","created":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T09:59:22Z","timestamp":1423216762000},"page":"168-176","source":"Crossref","is-referenced-by-count":12,"title":["Genetic polymorphisms of serum amyloid A1 and coronary artery disease risk"],"prefix":"10.1111","volume":"85","author":[{"given":"X.","family":"Xie","sequence":"first","affiliation":[{"name":"Department of coronary artery disease, Heart center First Affiliated Hospital of Xinjiang Medical University Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u2010T.","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of coronary artery disease, Heart center First Affiliated Hospital of Xinjiang Medical University Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u2010N.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of coronary artery disease, Heart center First Affiliated Hospital of Xinjiang Medical University Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X\u2010M.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of coronary artery disease, Heart center First Affiliated Hospital of Xinjiang Medical University Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u2010Y.","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of coronary artery disease, Heart center First Affiliated Hospital of Xinjiang Medical University Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Liu","sequence":"additional","affiliation":[{"name":"Coronary Artery Disease Research Laboratory Xinjiang Key Laboratory of Cardiovascular Disease Research Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of coronary artery disease, Heart center First Affiliated Hospital of Xinjiang Medical University Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z\u2010Y.","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of coronary artery disease, Heart center First Affiliated Hospital of Xinjiang Medical University Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z\u2010X.","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of coronary artery disease, Heart center First Affiliated Hospital of Xinjiang Medical University Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of coronary artery disease, Heart 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