{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T20:44:58Z","timestamp":1783543498798,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T00:00:00Z","timestamp":1423180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tissue Antigens"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Killer cell immunoglobulin\u2010like receptors (<jats:styled-content style=\"fixed-case\">KIR<\/jats:styled-content>) are expressed mainly in natural killer cells and specifically recognize human leukocyte antigen (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>) class I molecules. The repertoire of <jats:styled-content style=\"fixed-case\">KIR<\/jats:styled-content> genes and <jats:styled-content style=\"fixed-case\">KIR<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> pairs is known to play a key role in the susceptibilities to and the outcomes of several diseases, including malaria. The aim of this study was to investigate the distribution of <jats:styled-content style=\"fixed-case\">KIR<\/jats:styled-content> genes, <jats:styled-content style=\"fixed-case\">KIR<\/jats:styled-content> genotypes and <jats:styled-content style=\"fixed-case\">KIR\u2013HLA<\/jats:styled-content> pair combinations in a population naturally exposed to malaria from Brazilian Amazon. All 16 <jats:styled-content style=\"fixed-case\">KIR<\/jats:styled-content> genes investigated were present in the studied population. Overall, 46 <jats:styled-content style=\"fixed-case\">KIR<\/jats:styled-content> genotypes were defined. The two most common genotypes in the Porto Velho communities, genotypes 1 and 2, were present at similar frequencies as in the Americas. Principal component analysis based on the frequencies of the <jats:styled-content style=\"fixed-case\">KIR<\/jats:styled-content> genes placed the Porto Velho population closer to the Venezuela Mestizos, <jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content> California hispanic and Brazil Paran\u00e1 Mixed in terms of <jats:styled-content style=\"fixed-case\">KIR<\/jats:styled-content> gene frequencies. This analysis highlights the multi\u2010ethnic profile of the Porto Velho population. Most of the individuals were found to have at least one inhibitory <jats:styled-content style=\"fixed-case\">KIR\u2013HLA<\/jats:styled-content> pair. Seventy\u2010five <jats:styled-content style=\"fixed-case\">KIR\u2013HLA<\/jats:styled-content> pair combinations were identified. The <jats:italic>KIR\u20102DL2\/3_HLA\u2010C1, KIR3DL1_HLA\u2010Bw4<\/jats:italic> and <jats:italic>KIR2DL1_HLA\u2010C2<\/jats:italic> pairs were the most common. There was no association between <jats:styled-content style=\"fixed-case\">KIR<\/jats:styled-content> genes, <jats:styled-content style=\"fixed-case\">KIR<\/jats:styled-content> genotypes or <jats:styled-content style=\"fixed-case\">KIR\u2013HLA<\/jats:styled-content> pair combinations and malaria susceptibility in the studied population. This is the first report on the distribution of <jats:styled-content style=\"fixed-case\">KIR<\/jats:styled-content> and known <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> ligands in the Porto Velho population. Taken together, these results should provide baseline information that will be relevant to population evolutionary history, malaria and other diseases studies in populations of the Brazilian Amazon.<\/jats:p>","DOI":"10.1111\/tan.12523","type":"journal-article","created":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T11:19:25Z","timestamp":1423221565000},"page":"190-199","source":"Crossref","is-referenced-by-count":11,"title":["Killer cell immunoglobulin\u2010like receptor (<scp>KIR<\/scp>) gene diversity in a population naturally exposed to malaria in Porto Velho, Northern Brazil"],"prefix":"10.1111","volume":"85","author":[{"given":"D. S.","family":"Perce\u2010da\u2010Silva","sequence":"first","affiliation":[{"name":"Laboratory of Simulids and Onchocerciasis \u201cMalaria and Onchocerciasis Research\u201d Oswaldo Cruz Institute, Oswaldo Cruz Foundation  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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