{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:18:45Z","timestamp":1760242725816,"version":"3.37.3"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T00:00:00Z","timestamp":1428969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tissue Antigens"],"published-print":{"date-parts":[[2015,6]]},"abstract":"Abstract<\/jats:title>Downregulation of major histocompatibility complex class I chain\u2010related molecule A (MICA<\/jats:styled-content>) and upregulation of human leukocyte antigen G (HLA<\/jats:styled-content>\u2010G) on the tumor cells are important immune escape mechanisms for different epithelial tumors. In addition, upregulation of the soluble forms of the latter molecules in serum leads to peripheral T\u2010cell and natural killer (NK<\/jats:styled-content>)\u2010cell tolerance. As for cervical cancer, it remains unknown whether soluble MICA<\/jats:styled-content> (sMICA<\/jats:styled-content>) and soluble HLA<\/jats:styled-content>\u2010G (sHLA<\/jats:styled-content>\u2010G) concentrations are related to tumor characteristics or patient survival rates. We measured sMICA<\/jats:styled-content> and sHLA<\/jats:styled-content>\u2010G in pre\u2010treatment sera of a large cohort of cervical cancer patients (n<\/jats:italic>\u2009=\u2009366) by enzyme\u2010linked immunosorbent assay (ELISA<\/jats:styled-content>). We detected a median sMICA<\/jats:styled-content> of 174.73\u2009pg\/ml and a median sHLA<\/jats:styled-content>\u2010G of 5.35\u2009U\/ml. We did not find an association between sHLA<\/jats:styled-content>\u2010G levels and clinicopathological characteristics. In adenocarcinoma, low sMICA<\/jats:styled-content> concentration was positively related to recurrent disease, a higher International Federation of Gynecology and Obstetrics (FIGO<\/jats:styled-content>) stage and vaginal involvement (Mann\u2013Whitney U<\/jats:italic>\u2010test; P<\/jats:italic>\u2009=\u20090.018, P<\/jats:italic>\u2009=\u20090.042 and P<\/jats:italic>\u2009=\u20090.013, respectively). In the latter patient group, high sMICA<\/jats:styled-content> levels were associated with better disease\u2010free survival (DFS<\/jats:styled-content>) and disease\u2010specific survival (DSS<\/jats:styled-content>) (P<\/jats:italic>\u2009=\u20090.011 and P<\/jats:italic>\u2009=\u20090.047). After adjusting for confounding factors, high sMICA<\/jats:styled-content> proved to be an independent predictor for a better DFS<\/jats:styled-content> and DSS<\/jats:styled-content> [HR<\/jats:styled-content> 0.16; 95% confidence interval (CI<\/jats:styled-content>) 0.04\u20130.64; P<\/jats:italic>\u2009=\u20090.009 and HR<\/jats:styled-content> 0.12; 95% CI<\/jats:styled-content> 0.03\u20130.50; P<\/jats:italic>\u2009=\u20090.004]. sHLA<\/jats:styled-content>\u2010G did not influence survival in cervical cancer patients, regardless of histology. We conclude that cervical adenocarcinoma patients with high sMICA<\/jats:styled-content> levels have an increased DFS and DSS. This data warrants a prospective trial to study the functional role of sMICA<\/jats:styled-content> in cervical adenocarcinoma.\n<\/jats:p>","DOI":"10.1111\/tan.12562","type":"journal-article","created":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T10:52:53Z","timestamp":1429008773000},"page":"476-483","source":"Crossref","is-referenced-by-count":18,"title":["High levels of soluble MICA<\/scp> are significantly related to increased disease\u2010free and disease\u2010specific survival in patients with cervical adenocarcinoma"],"prefix":"10.1111","volume":"85","author":[{"given":"S.","family":"Samuels","sequence":"first","affiliation":[{"name":"Department of Gynecology Netherlands Cancer Institute\u00a0\u2013\u00a0Antoni van Leeuwenhoek (in collaboratation within the Centre for Gynecologic Oncology Amsterdam (CGOA)) Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"Ferns","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology VU University Medical Center (in collaboratation within the Centre for Gynecologic Oncology Amsterdam (CGOA)) Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam Medical Center (in collaboratation within the Centre for Gynecologic Oncology Amsterdam (CGOA)) Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. P.","family":"van Straalen","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry Amsterdam Medical Center Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. R.","family":"Buist","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Amsterdam Medical Center (in collaboratation within the Centre for Gynecologic Oncology Amsterdam (CGOA)) Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. J.","family":"Zijlmans","sequence":"additional","affiliation":[{"name":"Department of Gynecology Netherlands Cancer Institute\u00a0\u2013\u00a0Antoni van Leeuwenhoek (in collaboratation within the Centre for Gynecologic Oncology Amsterdam (CGOA)) Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. G.","family":"Kenter","sequence":"additional","affiliation":[{"name":"Department of Gynecology Netherlands Cancer Institute\u00a0\u2013\u00a0Antoni van Leeuwenhoek (in collaboratation within the Centre for Gynecologic Oncology Amsterdam (CGOA)) Amsterdam the Netherlands"},{"name":"Department of Obstetrics and Gynecology VU University Medical Center (in collaboratation within the Centre for Gynecologic Oncology Amsterdam (CGOA)) Amsterdam the Netherlands"},{"name":"Department of Obstetrics and Gynecology Amsterdam Medical Center (in collaboratation within the Centre for Gynecologic Oncology Amsterdam (CGOA)) Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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