{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:20:40Z","timestamp":1789010440834,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T00:00:00Z","timestamp":1433203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003549","name":"Orsz\u00e1gos Tudom\u00e1nyos Kutat\u00e1si Alapprogramok","doi-asserted-by":"publisher","award":["k104903"],"award-info":[{"award-number":["k104903"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tissue Antigens"],"published-print":{"date-parts":[[2015,7]]},"abstract":"The presence of null alleles may affect the outcome of stem cell transplantation. HLA<\/jats:styled-content>\u2010C*04:09N<\/jats:styled-content><\/jats:italic> was defined as \u2018common\u2019 with a frequency of 2\u20135\/1000 in Caucasians, and its presence is routinely tested as part of haplotypes HLA<\/jats:styled-content>\u2010A*02:01\/A*23:01\u2010B*44:03\u2010DRB1<\/jats:styled-content>*07:01\u2010DQB1<\/jats:styled-content>*02:01<\/jats:italic>. We aimed to investigate HLA<\/jats:styled-content>\u2010C*04:09N<\/jats:styled-content><\/jats:italic> in a representative Hungarian cohort. HLA<\/jats:styled-content>\u2010typing data of 7345 unrelated persons were analyzed. The presence of HLA<\/jats:styled-content>\u2010C*04:09N<\/jats:styled-content><\/jats:italic> was excluded in 157 chromosomes with either serology typing or with an allele\u2010specific polymerase chain reaction for HLA<\/jats:styled-content>\u2010C*04:09N<\/jats:styled-content><\/jats:italic>. HLA<\/jats:styled-content>\u2010C*04:09N<\/jats:styled-content><\/jats:italic> was identified in a single chromosome with HLA<\/jats:styled-content>\u2010A*02<\/jats:italic>, B*44<\/jats:italic>, C*04<\/jats:italic>, DRB1<\/jats:styled-content>*07<\/jats:italic> resulting in a HLA<\/jats:styled-content>\u2010C*04:09N<\/jats:styled-content><\/jats:italic> allele frequency of 0.0068% (1\/14,690). This is approximately a 10\u2010 to 40\u2010fold lower frequency compared with the previous data. Our results emphasize the need of precise local population\u2010specific HLA<\/jats:styled-content>\u2010data, allowing appropriate modifications of local HLA<\/jats:styled-content>\u2010typing protocols.<\/jats:p>","DOI":"10.1111\/tan.12587","type":"journal-article","created":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T23:42:36Z","timestamp":1433288556000},"page":"32-35","source":"Crossref","is-referenced-by-count":3,"title":["Low occurrence of the HLA\u2010C*04:09N<\/i> allele in a large Hungarian cohort"],"prefix":"10.1111","volume":"86","author":[{"given":"A.","family":"Bors","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Diagnostics Hungarian National Blood Transfusion Service Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Inotai","sequence":"additional","affiliation":[{"name":"Laboratory of Transplantation Immunogenetics Hungarian National Blood Transfusion Service Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Andrikovics","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Diagnostics Hungarian National Blood Transfusion Service Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Benk\u0151","sequence":"additional","affiliation":[{"name":"Laboratory of Transplantation Immunogenetics Hungarian National Blood Transfusion Service Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Boros\u2010Major","sequence":"additional","affiliation":[{"name":"Laboratory of Transplantation Immunogenetics Hungarian National Blood Transfusion Service Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Ill\u00e9s","sequence":"additional","affiliation":[{"name":"Laboratory of Transplantation Immunogenetics Hungarian National Blood Transfusion Service Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Szilv\u00e1si","sequence":"additional","affiliation":[{"name":"Laboratory of Transplantation Immunogenetics Hungarian National Blood Transfusion Service Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gelle\u2010Hoss\u00f3","sequence":"additional","affiliation":[{"name":"Bone Marrow Donor Registry Hungarian National Blood Transfusion Service Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Rajczy","sequence":"additional","affiliation":[{"name":"Bone Marrow Donor Registry Hungarian National Blood Transfusion Service Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tordai","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Diagnostics Hungarian National Blood Transfusion Service Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,2]]},"reference":[{"key":"e_1_2_4_2_1","unstructured":"HLA Nomenclature.http:\/\/hla.alleles.org(accessed on 1 October 2014)."},{"key":"e_1_2_4_3_1","unstructured":"CWD alleles.http:\/\/igdawg.org\/cwd.html(accessed on 1 October 2014)."},{"key":"e_1_2_4_4_1","unstructured":"IMGT Database.http:\/\/www.ebi.ac.uk\/ipd\/imgt\/hla\/(accessed on 1 October 2014)."},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12093"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2002.590204.x"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(02)00376-2"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2012.12.007"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2003.11.001"},{"key":"e_1_2_4_10_1","first-page":"351","article-title":"Identification of HLA\u2010Cw*0409N and its distribution in blood donors resident in Wales","volume":"29","author":"Downing J","year":"2002","journal-title":"Eur J Immunogenet"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2006.08.201"},{"key":"e_1_2_4_12_1","unstructured":"Allel frequencies in worldwide populations.http:\/\/www.allelefrequencies.net(accessed on 1 October 2014)."},{"key":"e_1_2_4_13_1","unstructured":"Be\u2010the\u2010match.https:\/\/bioinformatics.bethematchclinical.org\/(accessed on 1 October 2014)."}],"container-title":["Tissue Antigens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftan.12587","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.12587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T23:13:46Z","timestamp":1696202026000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tan.12587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,2]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/tan.12587"],"URL":"https:\/\/doi.org\/10.1111\/tan.12587","archive":["Portico"],"relation":{},"ISSN":["0001-2815","1399-0039"],"issn-type":[{"value":"0001-2815","type":"print"},{"value":"1399-0039","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,2]]}}}