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Despite the fact that acute phases of herpesviral replication are usually confined and controlled by a concerted action of all branches of the healthy immune system, sterile immunity is never reached. To accomplish this, herpesviruses evolved the unique ability to outlast episodes of efficient immunity in a dormant state called latency and a remarkable array of immune antagonists which counteract most (if not all) relevant aspects of intrinsic, innate and adaptive immune responses. Certain psychological and physiological conditions (such as stress, immuno\u2010suppression or pregnancy) predispose for viral reactivation which can lead to recurrent disease and virus spread. One important pillar of immunity is the innate immune system. The leading cytokines of the innate immune response are interferons (<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">IFNs<\/jats:styled-content> reinforce intrinsic immunity, induce a cell\u2010intrinsic antiviral state and recruit and orchestrate adaptive immunity. Consistently, individuals lacking a functional <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content> system suffer from otherwise harmless opportunists and live\u2010attenuated vaccines. The selective pressure elicited by <jats:styled-content style=\"fixed-case\">IFNs<\/jats:styled-content> drove herpesviruses to evolve numerous <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content> antagonistic gene products. A molecular in\u2010depth understanding of (herpes\u2010) viral <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content> antagonists might allow the design of novel antiviral drugs which reconstitute <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content> responses by blocking the antagonistic function and thereby help the host to help himself. Additionally, virus mutants lacking immune evasins constitute promising candidates for vaccine viruses. Here we summarize the current knowledge on <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content> antagonistic strategies of the eight human herpesviruses and try to decipher common strategies.<\/jats:p>","DOI":"10.1111\/tan.12594","type":"journal-article","created":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T08:58:08Z","timestamp":1434013088000},"page":"1-13","source":"Crossref","is-referenced-by-count":19,"title":["Attack, parry and riposte: molecular fencing between the innate immune system and human herpesviruses"],"prefix":"10.1111","volume":"86","author":[{"given":"V. T. 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