{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:41:20Z","timestamp":1773409280695,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T00:00:00Z","timestamp":1435104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81222022"],"award-info":[{"award-number":["81222022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271747"],"award-info":[{"award-number":["81271747"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81273301"],"award-info":[{"award-number":["81273301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Basic Research Program of China","award":["2012CB722404"],"award-info":[{"award-number":["2012CB722404"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tissue Antigens"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our recent targeted sequencing study identified a missense single\u2010nucleotide polymorphism rs72474224 (c.<jats:styled-content style=\"fixed-case\">324C<\/jats:styled-content>&gt;T) in <jats:italic><jats:styled-content style=\"fixed-case\">GJB2<\/jats:styled-content><\/jats:italic>. To investigate the correlation between rs72474224 (c.<jats:styled-content style=\"fixed-case\">324C<\/jats:styled-content>&gt;T) and subphenotypes of psoriasis, genotype data for rs72474224 (c.<jats:styled-content style=\"fixed-case\">324C<\/jats:styled-content>&gt;T, p.<jats:styled-content style=\"fixed-case\">Val37Ile<\/jats:styled-content>) was analyzed in 9946 cases and 9906 controls. The additive model provided the best fit for rs72474224 (<jats:italic>P<\/jats:italic> = 7.34 \u00d7 10<jats:sup>\u22129<\/jats:sup>). The genotypic and allelic frequency distributions were associated with plaque psoriasis in case\u2010only (<jats:italic>P<\/jats:italic><jats:sub>genotype<\/jats:sub> = 2.67 \u00d7 10<jats:sup>\u22123<\/jats:sup>, <jats:italic>P<\/jats:italic><jats:sub>allele<\/jats:sub> = 6.22 \u00d7 10<jats:sup>\u22124<\/jats:sup>) and subphenotype\u2010control (<jats:italic>P<\/jats:italic><jats:sub>genotype<\/jats:sub> = 1.58 \u00d7 10<jats:sup>\u221211<\/jats:sup>, <jats:italic>P<\/jats:italic><jats:sub>allele<\/jats:sub> = 8.16 \u00d7 10<jats:sup>\u221212<\/jats:sup>) analyses. No other significant difference was found in case\u2010only analyses. Rs72474224 in <jats:styled-content style=\"fixed-case\">GJB2<\/jats:styled-content> is preferentially associated with plaque psoriasis in Chinese population and might contribute to the complexity of psoriasis clinical features.<\/jats:p>","DOI":"10.1111\/tan.12595","type":"journal-article","created":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T06:25:25Z","timestamp":1435127125000},"page":"134-138","source":"Crossref","is-referenced-by-count":8,"title":["A genetic coding variant rs72474224 in GJB2 is associated with clinical features of psoriasis vulgaris in a Chinese Han population"],"prefix":"10.1111","volume":"86","author":[{"given":"F.","family":"Yao","sequence":"first","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology Anhui Medical University  Hefei China"},{"name":"State Key Laboratory Incubation Base of Dermatology Anhui Medical University  Hefei China"},{"name":"Department of Dermatology at Anqing Hospital Anhui Medical University  Hefei 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