{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T04:17:22Z","timestamp":1783052242546,"version":"3.54.6"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T00:00:00Z","timestamp":1436227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003549","name":"Orsz\u00e1gos Tudom\u00e1nyos Kutat\u00e1si Alapprogramok","doi-asserted-by":"publisher","award":["K104903"],"award-info":[{"award-number":["K104903"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["BM0803"],"award-info":[{"award-number":["BM0803"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swiss FNS","award":["31003A_144180"],"award-info":[{"award-number":["31003A_144180"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tissue Antigens"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Systematic analyses of human leukocyte antigen (<jats:styled-content style=\"fixed-case\"><jats:italic>HLA<\/jats:italic><\/jats:styled-content>) profiles in different populations may increase the efficiency of bone marrow donor selection and help reconstructing human peopling history. We typed <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010A, \u2010<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>,<\/jats:italic> and <jats:italic>\u2010<jats:styled-content style=\"fixed-case\">DRB1<\/jats:styled-content><\/jats:italic> allele groups in two bone marrow donor cohorts of 2402 Hungarians and 186 Hungarian Gypsies and compared them with several Central\u2010European, Spanish Gypsy, and Indian populations. Our results indicate that different European Gypsy populations share a common origin but diverged genetically as a consequence of founder effect and rapid genetic drift, whereas other European populations are related genetically in relation to geography. This study also suggests that while <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010A<\/jats:italic> accurately depicts the effects of genetic drift, <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B<\/jats:italic>, and <jats:italic>\u2010<jats:styled-content style=\"fixed-case\">DRB1<\/jats:styled-content><\/jats:italic> conserve more signatures of ancient population relationships, as a result of balancing selection.<\/jats:p>","DOI":"10.1111\/tan.12600","type":"journal-article","created":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T07:14:57Z","timestamp":1436253297000},"page":"115-121","source":"Crossref","is-referenced-by-count":13,"title":["<scp>HLA<\/scp> genetic diversity in Hungarians and Hungarian Gypsies: complementary differentiation patterns and demographic signals revealed by <scp>HLA<\/scp>\u2010A, \u2010<scp>B<\/scp> and \u2010<scp>DRB1<\/scp> in Central Europe"],"prefix":"10.1111","volume":"86","author":[{"given":"D.","family":"Inotai","sequence":"first","affiliation":[{"name":"Laboratory of Transplantation Immunogenetics Hungarian National Blood Transfusion Service  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Szilvasi","sequence":"additional","affiliation":[{"name":"Laboratory of Transplantation Immunogenetics Hungarian National Blood Transfusion Service  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Benko","sequence":"additional","affiliation":[{"name":"Laboratory of Transplantation Immunogenetics Hungarian National Blood Transfusion Service  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Boros\u2010Major","sequence":"additional","affiliation":[{"name":"Laboratory of Transplantation Immunogenetics Hungarian National Blood Transfusion Service  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Illes","sequence":"additional","affiliation":[{"name":"Laboratory of Transplantation Immunogenetics Hungarian National Blood Transfusion Service  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bors","sequence":"additional","affiliation":[{"name":"Molecular Diagnostics Hungarian National Blood Transfusion Service  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. P.","family":"Kiss","sequence":"additional","affiliation":[{"name":"Molecular Diagnostics Hungarian National Blood Transfusion Service  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Rajczy","sequence":"additional","affiliation":[{"name":"Bone Marrow Donor Registry Hungarian Blood Transfusion Service  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gelle\u2010Hoss\u00f3","sequence":"additional","affiliation":[{"name":"Bone Marrow Donor Registry Hungarian Blood Transfusion Service  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Buhler","sequence":"additional","affiliation":[{"name":"Laboratory of Anthropology, Genetics and Peopling History, Department of Genetics and Evolution \u2013 Anthropology Unit University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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