{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:19:00Z","timestamp":1787015940106,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T00:00:00Z","timestamp":1438214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tissue Antigens"],"published-print":{"date-parts":[[2015,9]]},"abstract":"Abstract<\/jats:title>\n \n In this brief communication, we investigate the role of\n DEFB103<\/jats:styled-content>\n gene copy number variation (\n CNV<\/jats:styled-content>\n ) in ankylosing spondylitis (\n AS<\/jats:styled-content>\n ) susceptibility. A total of 807 Chinese individuals including 406\n AS<\/jats:styled-content>\n patients and 401 controls were enrolled. The\n DEFB103<\/jats:styled-content>\n copy number was measured by two sets of probes to obtain a stable result in a custom\u2010by\u2010design Multiplex\n \n AccuCopy\n \u2122<\/jats:sup>\n <\/jats:styled-content>\n kit (Genesky Biotechnologies Inc., Shanghai, China) based on a multiplex fluorescence competitive polymerase chain reaction (\n PCR<\/jats:styled-content>\n ) principle. The copy number of\n DEFB103<\/jats:styled-content>\n ranged from 2 to 6 in both\n AS<\/jats:styled-content>\n patients and controls. Mann\u2013Whitney\n U<\/jats:italic>\n test and chi\u2010squared test were performed to analyze the difference of\n DEFB103<\/jats:styled-content>\n copy number between\n AS<\/jats:styled-content>\n patients and controls while no statistical difference has been found. We considered the copy number of\n DEFB103<\/jats:styled-content>\n gene may not associate with susceptibility to\n AS<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1111\/tan.12630","type":"journal-article","created":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T04:35:01Z","timestamp":1438230901000},"page":"195-198","source":"Crossref","is-referenced-by-count":5,"title":["Association between\n DEFB103<\/scp>\n gene copy number variation and ankylosing spondylitis: a case\u2013control study"],"prefix":"10.1111","volume":"86","author":[{"given":"G.","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health, Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health, Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health, Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health, Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health, Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health, Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health, Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health, Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health, Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health, Anhui Medical University Hefei 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Medical Research University of Tasmania Hobart Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health, Anhui Medical University Hefei China"},{"name":"Department of Rheumatism and Immunity The First Affiliated Hospital of Anhui Medical University Hefei China"},{"name":"Menzies Institute for Medical Research University of Tasmania Hobart 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