{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:43:06Z","timestamp":1787168586044,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,28]],"date-time":"2015-12-28T00:00:00Z","timestamp":1451260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HLA"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We characterized 549 new human leukocyte antigen (\n                    <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\n                    ) class I and class\n                    <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n                    alleles found in newly registered stem cell donors as a result of high\u2010throughput\n                    <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\n                    typing. New alleles include 101\n                    <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\n                    \u2010A, 132\n                    <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\n                    \u2010B, 105\n                    <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\n                    \u2010C, 2\n                    <jats:styled-content style=\"fixed-case\">HLA\u2010DRB1<\/jats:styled-content>\n                    , 89\n                    <jats:styled-content style=\"fixed-case\">HLA\u2010DQB1<\/jats:styled-content>\n                    and 120\n                    <jats:styled-content style=\"fixed-case\">HLA\u2010DPB1<\/jats:styled-content>\n                    alleles. Mainly, new alleles comprised single nucleotide variations when compared with homologous sequences. We identified nonsynonymous nucleotide mutations in 70.7% of all new alleles, synonymous variations in 26.4% and nonsense substitutions in 2.9% (null alleles). Some new alleles (55, 10.0%) were found multiple times,\n                    <jats:styled-content style=\"fixed-case\">HLA\u2010DPB1<\/jats:styled-content>\n                    alleles being the most frequent among these. Furthermore, as several new alleles were identified in individuals from ethnic minority groups, the relevance of recruiting donors belonging to such groups and the importance of ethnicity data collection in donor centers and registries is highlighted.\n                  <\/jats:p>","DOI":"10.1111\/tan.12721","type":"journal-article","created":{"date-parts":[[2015,12,28]],"date-time":"2015-12-28T00:43:12Z","timestamp":1451263392000},"page":"31-35","source":"Crossref","is-referenced-by-count":15,"title":["Detection of 549 new\n                    <scp>HLA<\/scp>\n                    alleles in potential stem cell donors from the United States, Poland and Germany"],"prefix":"10.1111","volume":"87","author":[{"given":"C. J.","family":"Hern\u00e1ndez\u2010Frederick","sequence":"first","affiliation":[{"name":"DKMS German Bone Marrow Donor Center  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Cereb","sequence":"additional","affiliation":[{"name":"HistoGenetics Inc.  Ossining NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. S.","family":"Giani","sequence":"additional","affiliation":[{"name":"DKMS German Bone Marrow Donor Center  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Ruppel","sequence":"additional","affiliation":[{"name":"Delete Blood Cancer DKMS US  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Maraszek","sequence":"additional","affiliation":[{"name":"DKMS Polska  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Pingel","sequence":"additional","affiliation":[{"name":"DKMS German Bone Marrow Donor Center  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sauter","sequence":"additional","affiliation":[{"name":"DKMS German Bone Marrow Donor Center  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. H.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"DKMS German Bone Marrow Donor Center  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Y.","family":"Yang","sequence":"additional","affiliation":[{"name":"HistoGenetics Inc.  Ossining NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,28]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2010.01466.x"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1161"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2009.01330.x"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12581"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12304"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12432"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2015.09.015"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086605"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2009.55"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2012.10.029"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-15-63"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2015.03.001"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2015.07.034"}],"container-title":["HLA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftan.12721","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.12721","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tan.12721","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tan.12721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T10:53:43Z","timestamp":1696157623000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tan.12721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,28]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/tan.12721"],"URL":"https:\/\/doi.org\/10.1111\/tan.12721","archive":["Portico"],"relation":{},"ISSN":["2059-2302","2059-2310"],"issn-type":[{"value":"2059-2302","type":"print"},{"value":"2059-2310","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,28]]}}}