{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:05:17Z","timestamp":1761609917399},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,12]],"date-time":"2016-04-12T00:00:00Z","timestamp":1460419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003381","name":"Minist\u00e9rio da Educa\u00e7\u00e3o e Ci\u00eancia","doi-asserted-by":"publisher","award":["175038","175065"],"award-info":[{"award-number":["175038","175065"]}],"id":[{"id":"10.13039\/501100003381","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HLA"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The etiology of pemphigus vulgaris (PV) is multifactorial and includes genetic, environmental, hormonal, and immunological factors. Inheritance of certain Human class II leukocyte antigen (HLA) alleles is by far the best\u2010established predisposing factor for the development of PV. Class II HLA alleles vary among racial\/ethnic backgrounds. We have determined an association between HLA class II alleles and PV among the Serbian population. A total of 72 patients with confirmed diagnosis of PV were genotyped for HLA class II alleles. HLA frequencies were compared with unrelated healthy bone marrow donors. The statistical significance of differences between patients and controls was evaluated using Fisher's exact test. The <jats:italic>DRB1*04<\/jats:italic> and <jats:italic>DRB1*14<\/jats:italic> allelic groups were associated with PV (<jats:italic>P<\/jats:italic> adj = 4.45 \u00d7 10<jats:sup>\u221213<\/jats:sup> and 4.06 \u00d7 10<jats:sup>\u221219<\/jats:sup> respectively), while <jats:italic>HLA\u2010DRB1*11<\/jats:italic> was negatively associated with PV (<jats:italic>P<\/jats:italic> adj = 0.0067) suggesting a protective role. <jats:italic>DRB1*04:02<\/jats:italic>, <jats:italic>DRB1*14:04<\/jats:italic>, <jats:italic>DQB1*03:02<\/jats:italic> and <jats:italic>DQB1*05:03<\/jats:italic> alleles were shown to be strongly associated with PV (<jats:italic>P<\/jats:italic> adj = 1.63 \u00d7 10<jats:sup>\u221212<\/jats:sup>, 5.20 \u00d7 10<jats:sup>\u22127<\/jats:sup>, 1.28 \u00d7 10<jats:sup>\u22126<\/jats:sup>, and 4.44 \u00d7 10<jats:sup>\u22125<\/jats:sup>, respectively). The frequency of <jats:italic>HLA DRB1*04\u2010DQB1*03<\/jats:italic> and <jats:italic>HLA DRB1*14\u2010DQB1*05<\/jats:italic> haplotypes in PV patients was significantly higher than in controls (31.3% <jats:italic>vs<\/jats:italic> 8.8%, <jats:italic>P<\/jats:italic> adj =7.66 \u00d7 10<jats:sup>\u22128<\/jats:sup> and 30.6% vs 6.3%, <jats:italic>P<\/jats:italic> adj = 3.22 \u00d7 10<jats:sup>\u221210<\/jats:sup>, respectively). At high\u2010resolution level, statistical significance was observed in <jats:italic>HLA\u2010DRB1*04:02\u2010DQB1*03:02<\/jats:italic> and <jats:italic>HLA\u2010DRB1*14:04\u2010DQB1*05:03<\/jats:italic> haplotypes (<jats:italic>P<\/jats:italic> adj = 5.55 \u00d7 10<jats:sup>\u221212<\/jats:sup>, and <jats:italic>P<\/jats:italic> adj = 3.91 \u00d7 10<jats:sup>\u22126<\/jats:sup>, respectively). Our findings suggest that <jats:italic>HLA\u2010DRB1*04:02<\/jats:italic>, <jats:italic>DRB1*14:04<\/jats:italic>, <jats:italic>HLA\u2010DQB1* 03:02<\/jats:italic> and <jats:italic>DQB1*05:03<\/jats:italic> alleles and <jats:italic>HLA\u2010DRB1*04:02\u2010DQB1*03:02<\/jats:italic> and <jats:italic>HLA\u2010DRB1*14:04\u2010DQB1*05:03<\/jats:italic> haplotypes are genetic markers for susceptibility for PV, while <jats:italic>DRB1*11<\/jats:italic> allelic group appears protective in Serbian population.<\/jats:p>","DOI":"10.1111\/tan.12796","type":"journal-article","created":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T05:23:53Z","timestamp":1460525033000},"page":"367-374","source":"Crossref","is-referenced-by-count":12,"title":["Human leukocyte antigen class II (DRB1 and DQB1) alleles and haplotypes frequencies in patients with pemphigus vulgaris among the Serbian population"],"prefix":"10.1111","volume":"87","author":[{"given":"D.","family":"Zivanovic","sequence":"first","affiliation":[{"name":"Clinic of Dermatovenereology Clinical Center of Serbia  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bojic","sequence":"additional","affiliation":[{"name":"Faculty of Biology University of Belgrade  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Medenica","sequence":"additional","affiliation":[{"name":"Clinic of Dermatovenereology Clinical Center of Serbia  Belgrade Serbia"},{"name":"Department of Dermatovenereology, School of Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Andric","sequence":"additional","affiliation":[{"name":"Tissue Typing Department Blood Transfusion Institute of Serbia  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Popadic","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Immunology, School of Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930600971497"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12418"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2009.00743.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/iji.12052"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2005.09.003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.2000.0388"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1996.tb02689.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2013.12.009"},{"key":"e_1_2_7_10_1","unstructured":"AndricZ. 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